04 December 2019 : Clinical Research
Risk Factors of Secondary Vertebral Compression Fracture After Percutaneous Vertebroplasty or Kyphoplasty: A Retrospective Study of 650 PatientsZiqi Chen1BCE, Yanping Wu2BC, Shenghua Ning1CDF, Tianxiao Ma1BF, Zhanyong Wu1AB*
Med Sci Monit 2019; 25:9255-9261
BACKGROUND: In this study, we aimed to investigate the risk factors contributing to secondary vertebral compression fractures (SVCF) in patients undergoing percutaneous vertebroplasty (PVP) or kyphoplasty (PKP) due to osteoporotic vertebral compression fracture (OVCF).
MATERIAL AND METHODS: Between January 2010 and December 2017, 650 patients with regular follow-up were identified and retrospectively analyzed in this study. Of these patients, 410 patients underwent PVP and 240 patients underwent PKP surgery. Patients were followed for 24 months on average, ranging from 6 months to 36 months follow-up. Possible risk factors screened for were age, gender, regional distribution, outdoor activity (ODA), bone mineral density (BMD), surgical methods (unilateral or bilateral), bone cement dose, bone cement leakage, chronic disease history, postoperative anti-osteoporosis treatment, and level of preoperative OVCF. Logistic regression analysis was applied to determine potential risk factors.
RESULTS: As a result, 102 patients (15.7%) suffered SVCF after PVP/PKP surgery at the last follow-up. Binary logistic regression model showed that older age increased the risk of developing SVCF [odds ratio (OR)=2.48, P=0.031] while high-level BMD (OR=0.31, P<0.001) and ODA (OR=0.38, P=0.001) decreased the risk. Binary logistic regression model showed the following: Logit (P)=1.03+0.91X₁–1.18X₂–0.97X₃ (X₁=age, OR=2.48, P=0.031; X₂=BMD, OR=0.31, P<0.001; X₃=ODA, OR=0.38, P=0.001).
CONCLUSIONS: In conclusion, older age and lower BMD were identified as risk factors of SVCF for OVCF patients following PVP/PKP surgery, whereas more ODA played a protective role in SVCF development.
Keywords: Fractures, Compression, kyphoplasty, Osteoporosis, Risk Factors, vertebroplasty, Aged, Aged, 80 and over, Bone Cements, Bone Density, Logistic Models, Lumbar Vertebrae, Middle Aged, Odds Ratio, Osteoporotic Fractures, Retrospective Studies, Spinal Fractures, Thoracic Vertebrae, Treatment Outcome
01 October 2023 : EditorialEditorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air Pollution
Med Sci Monit 2023; 29:e942672
04 Oct 2023 : Clinical ResearchA Retrospective Study of 205 Patients with Complex Kidney Stones to Compare Outcomes from Super-Mini Percut...
Med Sci Monit In Press; DOI: 10.12659/MSM.941012
03 Oct 2023 : Clinical ResearchPrevalence and Risk Factors for Modic Changes in Symptomatic Cervical Ossification of the Posterior Longitu...
Med Sci Monit In Press; DOI: 10.12659/MSM.941674
03 Oct 2023 : Clinical ResearchTime-Dependent Factors Influencing Cardiocerebral Vascular Events in Chronic Hemodialysis Patients: Insight...
Med Sci Monit In Press; DOI: 10.12659/MSM.941553
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical ResearchPrevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292