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14 May 2019 : Animal Research  

Comparison of the Effects of Indobufen and Warfarin in a Rat Model of Adenine-Induced Chronic Kidney Disease

Xiaowei Lou123ABCDEF, Juan Jin123ABCDFG, Jianguang Gong123BCD, Li Zhao123BCD, Yiwen Li123AEFG*, Qiang He123AEFG

DOI: 10.12659/MSM.915590

Med Sci Monit 2019; 25:3566-3572

Abstract

BACKGROUND: Worldwide, the treatment of patients with chronic kidney disease (CKD) remains a challenge as warfarin treatment can be associated with severe adverse events related to bleeding. Alternative anticoagulants that can be used in CKD remain to be identified. This study aimed to compare the effects of indobufen, a new antiplatelet agent, with warfarin in a rat model of adenine-induced CKD.

MATERIAL AND METHODS: Forty-eight male Wistar rats were treated with intragastric adenine to create the rat model of CKD and were divided into four groups: an untreated control group (N=12), a group treated with dimethyl sulfoxide (DMSO) (N=12), a group treated with indobufen, (N=12) and a group treated with warfarin (N-12). Treatment was given for 4 weeks and 8 weeks. Kidney histology was performed, and the degree of fibrosis was quantified using Masson trichrome staining.

RESULTS: In the rat model of adenine-induced CKD, Masson trichrome staining showed that the degree of kidney fibrosis in the indobufen group (26%) was significantly reduced (p<0.05) when compared the DMSO group (58%) and the warfarin group (49%). Kidney fibrosis was associated with upregulation of 6-keto-PGI2/TXB2 in the rat kidney tissue.

CONCLUSIONS: In a rat model of adenine-induced CKD, preliminary findings showed that indobufen was associated with reduced kidney fibrosis when compared with warfarin.

Keywords: Fibrosis, Platelet Aggregation Inhibitors, Renal Insufficiency, Chronic, Adenine, Anticoagulants, Isoindoles, Kidney, Kidney Failure, Chronic, Phenylbutyrates, Rats, Wistar, Warfarin

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750