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20 January 2020 : Clinical Research  

Measurement of the Combined Levels of Serum Uric Acid and Alanine Aminotransferase and the Risk of Metabolic Syndrome in a Population Aged 60 Years or More in Northeastern China

Jiabei Wang1ABCDEF, Yingfang Wang2BC, Feng Chen2B, Guojing Ma2B, Difei Wang1AG*

DOI: 10.12659/MSM.916459

Med Sci Monit 2020; 26:e916459

Abstract

BACKGROUND: Serum uric acid (SUA) and alanine aminotransferase (ALT) levels are increased in patients with metabolic syndrome. This study aimed to investigate the association between the combined levels of SUA and ALT and the risk of metabolic syndrome in residents ≥60 years of age in Northeastern China.

MATERIAL AND METHODS: A population study included nine communities in Shenyang, Northeast China, and 3,998 participants (1,434 men and 2,564 women) who were ≥60 years old. SUA and ALT measurements (levels 1–3) and clinical parameters were recorded. Metabolic syndrome was diagnosed according to the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). The association between the combined SUA and ALT levels and metabolic syndrome was determined by multivariate logistic regression analysis in tertiles that included Groups 1–9.

RESULTS: The prevalence of metabolic syndrome was 43.2% (men), and 61.9% (women), and the prevalence and odds ratio (OR) values increased with increasing SUA and ALT levels. The OR values of metabolic syndrome in the ALT Groups 2–3 were 1.329 (95% CI, 1.137–1.554) and 2.362 (95% CI, 2.006–2.781), and in the SUA Groups 2–3 the OR values were 1.718 (95% CI, 1.466–2.015) and 2.743 (95% CI, 2.310–3.256). The OR of the combined increase in SUA and ALT and metabolic syndrome in Groups 1–9 ranged from 1.494–5.889 (all, p<0.05).

CONCLUSIONS: Increased combined SUA and ALT was more significantly associated with metabolic syndrome than an increase in SUA or ALT alone.

Keywords: Alanine Transaminase, Metabolic Syndrome X, Uric Acid, Aged, Aged, 80 and over, China, Middle Aged, Odds Ratio, Prevalence, Risk Factors

Errate

Med Sci Monit 2020; 26:e926434     https://medscimonit.com/abstract/index/idArt/926434

The authors informed the journal that several errors occurred in their manuscript and request the following to be corrected: 
1. The affiliation for Jiabei Wang should be corrected from
Department of Geriatric, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei, P.R. China
to: 
Department of Geriatric, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei, P.R. China
Department of Geriatric, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, P.R. China
2. The affiliation for Difei Wang should be corrected from:
Department of Geriatric, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei, P.R. China
to:
Department of Geriatric, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, P.R. China
Reference:
1. Wang J, Wang Y, Chen F, Ma G, Wang D. Measurement of the Combined Levels of Serum Uric Acid and Alanine Aminotransferase and the Risk of Metabolic Syndrome in a Population Aged 60 Years or More in Northeastern China. Med Sci Monit, 2020; 26: e916459.
doi: 10.12659/MSM.916459
 
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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750