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24 September 2019 : Clinical Research  

Diagnostic Accuracy of Acoustic Radiation Force Impulse (ARFI) and Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein (WFA⁺-M2BP) in Patients with Chronic Liver Disease

Chien-Cheng Chen12AEF, Hui-Ting Hsu3ACD, Yao-Li Chen45AF, Ran-Chou Chen1AF, Wen-Pei Wu6ACD, Chen-Te Chou567AEF*

DOI: 10.12659/MSM.916533

Med Sci Monit 2019; 25:7169-7174

Abstract

BACKGROUND: The present study assessed and compared the diagnostic accuracy of elastography (acoustic radiation force impulse, ARFI) with that of Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA⁺-M2BP) for estimating the stage of hepatic fibrosis in chronic liver disease patients.

MATERIAL AND METHODS: This retrospective cross-sectional study enrolled 70 chronic liver disease patients who underwent hepatectomy for hepatic tumors. ARFI and WFA⁺-M2BP serum level, underlying liver disease, and laboratory data for all patients were recorded. The stage of fibrosis was determined from a surgical specimen. The area under the receiver operating characteristic (ROC) curves (AUC) was measured to compare the diagnostic accuracy.

RESULTS: The ARFI and serum WFA⁺-M2BP levels had good performances for detecting severe fibrosis (≥F3). The AUC in characterization of fibrosis stage ≥F3 was 0.79 for ARFI and 0.71 for serum WFA⁺-M2BP levels. When comparing the diagnostic performances between ARFI and serum WFA⁺-M2BP levels for the severity of fibrosis stage, no significant differences were found. Then all patients were divided into 2 subgroups, the AUC for serum WFA⁺-M2BP levels was higher in the hepatitis C virus (HCV) subgroup than in the hepatitis B virus (HBV) subgroup when characterizing fibrosis stages ≥F3.

CONCLUSIONS: WFA⁺-M2BP is an accurate biomarker and is as good as ARFI in detecting severe fibrosis for chronic liver disease patients.

Keywords: Elasticity Imaging Techniques, Liver Cirrhosis, Wisteria, Area Under Curve, Cross-Sectional Studies, Hepacivirus, Hepatectomy, Hepatitis B virus, Hepatitis B, Chronic, Hepatitis C, Chronic, Membrane Glycoproteins, Plant Lectins, ROC Curve, Receptors, N-Acetylglucosamine

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750