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07 November 2019 : Review article  

Increased Levels of Glycated Hemoglobin A1c and Iron Deficiency Anemia: A Review

Wenjia Guo1E*, Qi Zhou2EG, Yanan Jia1EF, Jiancheng Xu1EFG

DOI: 10.12659/MSM.916719

Med Sci Monit 2019; 25:8371-8378

Abstract

Worldwide, the prevalence of diabetes remains high. Studies have shown that iron deficiency anemia (IDA) is associated with increased levels of glycated hemoglobin A1c (HbA1c), but the mechanism remains unclear. Hematological changes, iron metabolism, study methodology, and other factors could affect the results of diagnostic investigations, leading to false results. Red blood cell turnover in the bone marrow and the quality and heterogeneity of erythrocytes may influence the rate of hemoglobin glycation. By changing the structure of hemoglobin and inducing peroxidation, iron deficiency accelerates glycation. This review aims to discuss the possible causes of the association between increased levels of HbA1c and IDA.

Keywords: Anemia, Iron-Deficiency, Diabetes Mellitus, Type 2, Health Care Evaluation Mechanisms, Anemia, Blood Glucose, Diabetes Mellitus, Erythrocytes, Glycated Hemoglobin A, Hemoglobins, Iron, Prevalence

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DOI: 10.12659/MSM.943911

Med Sci Monit 2024; 30:e943911

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750