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24 November 2019 : Animal Research  

Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation

Tetsuo Nakajima1ABCDEFG*, Guillaume Vares2ABCDEFG, Yasuharu Ninomiya1BE, Bing Wang1BE, Takanori Katsube1BE, Kaoru Tanaka1BE, Kouichi Maruyama3BE, Mitsuru Nenoi4ACDEG

DOI: 10.12659/MSM.917207

Med Sci Monit 2019; 25:8920-8927


BACKGROUND: Several factors found in foods are beneficial to human health and they may contribute to radiation protection. Taking food factors could be an easy way to reduce the effects of radiation after nuclear accidents, as well as secondary radiation risks after cancer radiotherapy or space missions. Here, diallyl disulfide (DADS), a component of garlic oil, was studied for its ability to mitigate radiation damage.

MATERIAL AND METHODS: We investigated the effects of DADS on micronucleus (MN) formation and apoptosis in HepG2 cells by use of 4-Gy X-ray irradiation. We also assessed the effects of DADS on radiation damage in vivo by evaluating MN formation in bone marrow cells in mice (BALB/c, 8-week-old females) after oral intake of DADS prior to irradiation with 4 Gy. Several tissue effects were also investigated.

RESULTS: The presence of DADS inhibited MN formation, whereas DADS had no influence on the radiation-induced inhibition of cell cycle progression in HepG2 cells. An increase in apoptosis in HepG2 cells was induced after irradiation, and this effect was stronger in the presence of DADS than in its absence. In mice, when DADS was administered daily for 3 days prior to irradiation, MN formation in irradiated mice was decreased. The decrease in MN formation in mice was greater with 0.5% DADS compared to 1% DADS. Moreover, an increase in spleen weight observed 3 weeks after irradiation was suppressed in mice administered DADS.

CONCLUSIONS: DADS is a potential radiation-protective agent that effectively mitigates DNA damage, and its effects in the spleen observed after irradiation may be related to inflammation and carcinogenesis.

Keywords: DNA Damage, Garlic, Radiation Protection, Radiation-Protective Agents, Spleen, Allyl Compounds, Disulfides, Hep G2 Cells, Mice, Inbred BALB C, Radiation Injuries

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750