Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

14 November 2019 : Clinical Research  

Long-Term Results and Predictors of Survival After Conservative Breast Surgery for Breast Cancer During Pregnancy

Chen Feng1BCEF, Dingyue Yu2DF, Jun Qian1AEG*

DOI: 10.12659/MSM.917288

Med Sci Monit 2019; 25:8587-8594

Abstract

BACKGROUND: Breast cancer is one of the most frequently encountered malignancies in women. Although the prognosis is good for most breast cancer patients, little is known about the outcomes of breast carcinoma during pregnancy. The long-term results and predictors of survival of conservative breast surgery for breast cancer during pregnancy are especially unclear.

MATERIAL AND METHODS: Patients with primary diagnosis of breast cancer during pregnancy who received conservative breast surgery were recruited in this study from October 2009 to January 2015. Clinical data were collected and compared to individuals without associated pregnancies. The primary outcome disease-free survival (DFS) and the secondary outcome, overall survival (OS), were compared between the 2 groups (pregnant vs. nonpregnant women). Cox proportional hazards regression analysis was used to assess the potential predictors of survival for breast cancer patients during pregnancy.

RESULTS: Sixty-three pregnant patients underwent conservative breast carcinoma. The median gestational age was 26 weeks and the median age was 34 years. The nonpregnant group consists of 82 individuals with median age of 37 years. All the patients received chemotherapy after surgery. The follow-up period was 3 years. The 3-year DFS was 79.3% in the pregnant group and 81.7% in the nonpregnant group. The 3-year OS was 87.3% (pregnant) and 89% (nonpregnant), respectively. Multivariable analysis revealed that tumor stage and chemotherapy were independent predictors for survival.

CONCLUSIONS: Our study showed that conservative breast surgery is a reliable therapy for breast cancer patients during pregnancy, with similar DFS and OS compared to nonpregnant patients.

Keywords: Breast Neoplasms, Mastectomy, Segmental, Pregnancy, Prognosis, Case-Control Studies, Disease-Free Survival, Mastectomy, Middle Aged, Pregnancy Complications, Neoplastic, Treatment Outcome

Add Comment 0 Comments

967 19

Editorial

01 December 2023 : Editorial  

Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312

0:00

In Press

01 Dec 2023 : Clinical Research  

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Clinical Research  

Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...

Med Sci Monit In Press; DOI:  

29 Nov 2023 : Clinical Research  

Comparative Analysis of Intramedullary Nail versus Plate Fixation for Fibula Fracture in Supination Externa...

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750