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18 November 2019 : Clinical Research  

Platelet-to-Lymphocyte Ratio (PLR) Is Associated with Immune Thrombocytopenia (ITP) Recurrence: A Retrospective Cohort Study

Jun Song1BE, Chi Chen2C, Qing Wang1BF, Lin-Hui Wang1BDF, Jun Cao1BF, Peng-Xiang Guo1AG*

DOI: 10.12659/MSM.917531

Med Sci Monit 2019; 25:8683-8693

Abstract

BACKGROUND: Current guidelines are inadequate for use in predicting ITP recurrence. Therefore, our primary goal in this study was to investigate the association of platelet-to-lymphocyte ratio (PLR) at diagnosis with ITP recurrence in Chinese patients.

MATERIAL AND METHODS: We performed a historical cohort study and non-selectively enrolled 233 patients with newly-identified ITP from March 2013 to June 2017. The independent variable was PLR recorded at diagnosis and the dependent variable was recurrence-free survival (RFS) at 6 months. Data on the following variables were also collected for establishing a multivariate Cox regression model: demographic details, general details, and variables found to be closely related to PLR in previous studies, as well as risk factors for ITP recurrence.

RESULTS: During follow-up, 85 patients had an event within 6 months. At the range of 0.86–9.7 of PLR, a 1-unit increase in PLR was associated with a 13% decrease in ITP recurrence (hazard ratio: 0.87; 95% confidence interval: 0.78–0.97), whereas no association was detected at the range of 9.7–33.75 of PLR (hazard ratio: 0.99; 95% confidence interval: 0.95–1.04). An interaction test indicated that patients with HP infection (0.91 (0.86–1.97)) or diabetes history (0.86 (0.78–0.96)) showed a stronger association compared with patients without HP infection (1.01 (0.95–1.04) and those without diabetes (1.01 (0.97–1.04)).

CONCLUSIONS: Our findings suggest that PLR is a useful parameter to consider when hematologists attempt to assess the risk of recurrence in ITP patients receiving first-line therapy, and the nonlinearity of PLR and ITP recurrence risk must be fully considered when constructing predictive models.

Keywords: Blood Platelets, Purpura, Thrombocytopenic, Idiopathic, Recurrence, Adolescent, Aged, 80 and over, Cohort Studies, Disease-Free Survival, Lymphocyte Count, Lymphocytes, Platelet Count, Proportional Hazards Models, Thrombocytopenia

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750