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23 September 2019 : Laboratory Research  

Long Non-Coding RNA (LncRNA) UFC1/miR-34a Contributes to Proliferation and Migration in Breast Cancer

Ruilian Xie1ABCDEFG*, Maoyuan Wang2BCD, Wenting Zhou1CDEF, Dan Wang3ACF, Yan Yuan1CF, Huaqiu Shi1CF, Longqiu Wu1BEF

DOI: 10.12659/MSM.917562

Med Sci Monit 2019; 25:7149-7157

Abstract

BACKGROUND: At present, a number of long non-coding RNAs (lncRNAs) have been realized as the critical regulators of breast cancers. Current evidence indicates that dysregulation of UFC1 contributes to the tumorigenesis and progression of various types of human cancer. However, the roles of UFC1 in breast cancer are still unclear.

MATERIAL AND METHODS: Firstly, we measured the expression of UFC1 in breast cancer tissues and cells lines compared with corresponding controls. Then, cell functional assays were performed to determine the roles of UFC1 in breast cancer progression in vitro. Moreover, the correlation between UFC1 and miR-34a was determined by luciferase reporter assays. Further, the role of miR-34a in regulating biological function of breast cancer and its downstream target CXCL10 was applied by a series of functional assays.

RESULTS: In present study, we found that UFC1 was highly expressed in breast tissue and cells lines compared with normal tissues and cell lines. Silenced UFC1 suppressed multiple biological activities of breast cancer cells, which also functioned as a miR-34a sponge in breast cancer. Furthermore, over-expressing miR-34a could prominently suppress cell growth, invasion, migration and inducing apoptosis in breast cancer cells. In addition, we verified that miR-34a was a target of CXCL10 by bioinformatics analysis and luciferase reporter assay.

CONCLUSIONS: LncRNA UFC1 regulated biological activity of breast cancer via miR-34a/CXCL10 axis, providing a novel diagnosis biomarker and potential therapeutic target for breast cancer.

Keywords: Breast Diseases, MicroRNAs, RNA, Long Noncoding, Base Sequence, Breast Neoplasms, Chemokine CXCL10, Gene Expression Regulation, Neoplastic, Gene Silencing, Prognosis

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750