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07 December 2019 : Laboratory Research  

Protective Effect of β-Glucogallin on Damaged Cataract Against Methylglyoxal Induced Oxidative Stress in Cultured Lens Epithelial Cells

Ying Ma1CDEF, Fei Liu1CDF, Yanli Xu1ABCDEFG*

DOI: 10.12659/MSM.917869

Med Sci Monit 2019; 25:9310-9318


BACKGROUND: β-glucogallin (GG) is one of the major plant polyphenolic antioxidants that have been associated with positive effects on human health and are crucial in the developing defense mechanism against the risk of diseases. However, reports on the protective mechanism of GG in lens epithelial cells are limited.

MATERIAL AND METHODS: ARPE-19 cells (a human retinal epithelial cell line) were exposed to methylglyoxal (MG) with or without GG to illuminate the protective role of GG in counteracting the cataract signaling.

RESULTS: Cells predisposed to MG demonstrated an increase in oxidative stress with augmented (P<0.01) inflammatory cytokines such as cyclooxygenase (COX)-2, chemokine receptor CXCR4, interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule 1 (ICAM-1) genes. In addition, the expression of aldose reductase (AR) was increased to 2-fold with accumulated sorbitol in MG exposed cells compared to control. On the other hand, cells exposed to MG evidenced a 3-fold increase in RAGE (receptor for advanced glycation end products) and a 2-fold increase in NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) expression compared to control cells. Intriguingly, lens epithelial cells pre-treated with GG attenuated the reactive oxygen species levels with improved antioxidant enzymes. Simultaneously, the levels of AR and other inflammatory cytokines were observed in the levels closer to control cells in GG pre-treated cells.

CONCLUSIONS: Thus, the results of the present investigation show that GG may be a potential drug for the prevention of cataract development and progression.

Keywords: 3T3 Cells, Glucan 1,3-beta-Glucosidase, Hypercementosis, Leukemia, Lymphocytic, Chronic, B-Cell, Photosensitivity Disorders, Antioxidants, Cataract, Cell Line, Chemokine CCL2, Chemokines, China, Cytokines, Epithelial Cells, Glycation End Products, Advanced, Hydrolyzable Tannins, Intercellular Adhesion Molecule-1, Interleukin-6, Lens, Crystalline, Oxidative Stress, Pyruvaldehyde, Reactive Oxygen Species



12 September 2022 : Editorial  

Editorial: Treatment with Dual Incretin Receptor Agonists to Maintain Normal Glucose Levels May Also Maintain Normal Weight and Control Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)

Ana Luisa Ordóñez-Vázquez, Sofía Murúa Beltrán-Gall, Shreya C. Pal, Nahum Méndez-Sánchez
Liver Research Unit, Medica Sur Clinic Foundation, Mexico City, Mexico

DOI: 10.12659/MSM.938365

Med Sci Monit 2022; 28:e938365


30 September 2022 : Editorial  

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Med Sci Monit In Press; DOI: 10.12659/MSM.938532  

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750