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25 November 2019 : Clinical Research  

Prognostic Factors and Treatment Options for Patients with High-Grade Chondrosarcoma

Zhongyang Gao1ABCDEF, Teng Lu1BCE, Hui Song1CE, Zhengchao Gao1CD, Fenggang Ren2C, Pengrong Ouyang1BC, Yibin Wang1CD, Junjie Zhu3C, Songlin Zhou4EF, Xijing He1ADEFG*

DOI: 10.12659/MSM.917959

Med Sci Monit 2019; 25:8952-8967

Abstract

BACKGROUND: The goal of this study was to determine the prognostic factors exclusive for high-grade chondrosarcoma and whether adjuvant radiotherapy could achieve better overall survival (OS) or cancer-specific survival (CSS) for patients with high-grade chondrosarcoma.

MATERIAL AND METHODS: Surveillance, Epidemiology, and End Results (SEER) cancer registry database was utilized to extract the chondrosarcoma cases diagnosed between 1973 and 2014. Among these cases, the histological grades of poorly differentiated (grade 3) and undifferentiated (grade 4) were categorized as high-grade and included in this study. Chondrosarcoma OS and CSS were the primary outcomes in the present study. The log-rank test was performed for univariate analysis, and the Cox regression model was conducted for multivariate analysis.

RESULTS: A total of 743 patients with high-grade chondrosarcoma were identified in this study (430 cases were poorly differentiated tumors, and 313 cases were undifferentiated tumors). Age at diagnosis, pathological grade, histo-type, SEER stage, tumor size and surgical resection were identified as independent predictors in both OS and CSS analysis of high-grade chondrosarcoma. When stratified by histological grade, surgical resection remained the effective treatment. Strikingly, radiotherapy was determined as an independent protective factor in both OS and CSS analysis of undifferentiated (grade 4) dedifferentiated chondrosarcoma, and adjuvant radiotherapy combined surgical resection could improve both the OS and CSS of patients with undifferentiated myxoid and dedifferentiated chondrosarcoma compared with other treatment regimens.

CONCLUSIONS: Our study first demonstrated that adjuvant radiotherapy combined surgery could improve the survival of patients with undifferentiated myxoid and dedifferentiated chondrosarcoma. These results encourage the application of adjuvant radiotherapy for patients with high-grade chondrosarcoma and maximize the patients’ outcome.

Keywords: Chondrosarcoma, Radiotherapy, SEER Program, Multivariate Analysis, Radiotherapy, Adjuvant, Registries

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750