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13 August 2019 : Clinical Research  

Prognostic Value of Lymphovascular Invasion in Patients with Stage III Colorectal Cancer: A Retrospective Study

Jin-Wei Zhong1ADE, Shou-Xing Yang1CD, Ren-Pin Chen2BF, Yu-Hui Zhou1BF, Meng-Si Ye1BF, Lei Miao1BF, Zhan-Xiong Xue1ADG, Guang-Rong Lu1AEG*

DOI: 10.12659/MSM.918133

Med Sci Monit 2019; 25:6043-6050

Abstract

BACKGROUND: Lymph node metastasis and tumor progression depend on lymphovascular invasion (LVI). This study aimed to investigate the prognostic role of LVI in patients with stage III colorectal cancer (CRC) and to develop a prognostic nomogram.

MATERIAL AND METHODS: A retrospective study included 437 patients with stage III CRC. The impact of LVI on overall survival (OS) was analyzed with the Kaplan-Meier method and Cox regression model. A nomogram was constructed, and its predictive accuracy was evaluated using the concordance index (C-index) and the calibration plot.

RESULTS: LVI was found in 19.7% of cases of stage III CRCs and was significantly correlated with high tumor grade (poor differentiation) and advanced tumor stage (all P<0.05). Patients age, a family history of cancer in a first-degree relative, pre-treatment levels of carcinoembryonic antigen (CEA), prognostic nutritional index (PNI), histological tumor grade, tumor-node-metastasis (TNM) stage, and LVI were independent prognostic indicators (all P<0.05). Compared with the LVI(–) group, patients in the LVI(+) group showed a 1.748-fold increased risk of death (P=0.004) and a significantly reduced OS rate (P<0.001). In the prognostic nomogram, the C-index was significantly increased with LVI compared with the TNM stage alone (0.742 vs. 0.593; P<0.001). Calibration plots showed good fitness of the nomogram for prediction of survival. Comparison of the nomograms with and without LVI showed that inclusion of LVI improved the C-index from 0.715 to 0.742.

CONCLUSIONS: LVI was an indicator of more aggressive biological behavior and poor prognosis in patients with stage III CRC.

Keywords: Colorectal Neoplasms, Lymphatic Vessels, nomograms, Risk Factors, Aged, Aged, 80 and over, China, Kaplan-Meier Estimate, Lymph Nodes, Lymphatic Metastasis, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Prognosis, Retrospective Studies, Survival Rate

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Editorial

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Ana Luisa Ordóñez-Vázquez, Sofía Murúa Beltrán-Gall, Shreya C. Pal, Nahum Méndez-Sánchez
Liver Research Unit, Medica Sur Clinic Foundation, Mexico City, Mexico

DOI: 10.12659/MSM.938365

Med Sci Monit 2022; 28:e938365

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750