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13 November 2019 : Clinical Research  

Comparison of Dinoprostone and Oxytocin for the Induction of Labor in Late-Term Pregnancy and the Rate of Cesarean Section: A Retrospective Study in Ten Centers in South China

Yanxing Wei1ADEFG, Xueyuan Li12BCDF, Yinhui Zhang3B, Yuewen Guo4B, Baomin Yin5B, Dunjin Chen2B, Yi Chen6B, Yanping Yu7B, Bin Zhu8B, Yiwei Qin9B, Jianping Zhang10B, Zhijian Wang1ACDEFG*

DOI: 10.12659/MSM.918330

Med Sci Monit 2019; 25:8554-8561


BACKGROUND: Dinoprostone is the recommended primary option for induction of labor (IOL) in late-term pregnancies (LTPs). However, oxytocin is used in developing and rural areas, and studies have supported similar effectiveness for oxytocin and dinoprostone in reducing the rate of cesarean delivery of LTPs with a Bishop’s score of between 4–6. This study aimed to compare dinoprostone and oxytocin for IOL in LTPs and the rate of cesarean section in ten centers in South China.

MATERIAL AND METHODS: A retrospective study included 1,408 women with LTP, with subgroups including a Bishop’s score of 0–3 and 4–6. Rates of cesarean delivery were compared between women given vaginal dinoprostone and intravenous oxytocin for IOL. Secondary outcomes included the duration of labor, and maternal and fetal complications.

RESULTS: Comparison between women who received oxytocin (N=365) and dinoprostone (N=1,043) showed significantly lower rates of cesarean delivery with dinoprostone, but no significant difference between the subgroups with Bishop’s scores of 0–3 and 4–6. The interval between induction to labor and duration of the active phase of labor were significantly reduced in the dinoprostone group with a Bishop’s score of between 4–6.

CONCLUSIONS: For LTPs with a Bishop’s score of 0–3, dinoprostone was superior to oxytocin for IOL with a lower rate of cesarean delivery, but both agents had a similar outcome for women with a Bishop’s score of 4–6. These findings may have implications for the choice of agent used in IOL when dinoprostone is unavailable.

Keywords: Cervical Ripening, Cesarean Section, Dinoprostone, Labor, Induced, Oxytocin, Pregnancy, Prolonged, Labor, Obstetric, Oxytocics, Pregnancy, Pregnancy Trimester, Third, young adult

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750