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18 November 2019 : Clinical Research  

Use of Advanced Modalities Does Not Guarantee Early Detection of Small-Bowel Crohn’s Disease in the Absence of Complications

Si-Yuan Wu1ABCDEF, Chuan-Hua Yang1ACDEG*, Wei-Li Sun2BCD, Xiao Sun1B, Yao Zhang1D, Zhi-Zheng Ge1D

DOI: 10.12659/MSM.918413

Med Sci Monit 2019; 25:8704-8711


BACKGROUND: This study investigated the approach for detection of small-bowel (SB) Crohn’s disease (CD) in the absence of complications at diagnosis using advanced modalities.

MATERIAL AND METHODS: Patients diagnosed with CD in Renji Hospital from 2005 to 2014 were divided into 2 groups by year of diagnosis: 2005 to 2009 and 2010 to 2014. The modalities used and the clinical characteristics of patients were retrospectively examined.

RESULTS: Advanced modalities did not detect higher rate of non-stricturing/non-penetrating disease in 2010 to 2014 than older modalities in 2005 to 2009. Further analysis showed that a stricturing complication was significantly more common in patients with SB CD than in those who had CD with SB and colonic involvement, and the duration from symptom onset to lesion detection was significantly longer in patients with SB CD than in those who had CD with SB and colonic involvement. Fewer patients with SB CD underwent SB capsule endoscopy compared to the other advanced modalities. Abdominal pain (74.4%) was the most common presentation, and 94.0% patients with SB CD presented gastrointestinal bleeding and anemia.

CONCLUSIONS: Early detection of SB CD without complications remains difficult even if advanced modalities are introduced. Our hypothesis is that the fecal occult blood test and routine blood test should be administered to patients with abdominal pain or gastrointestinal manifestations. Once the patients are found to have GI bleeding or anemia, they would be further examined according to the guideline and SBCE would be used in the early stage of SB CD.

Keywords: Anemia, Capsule Endoscopes, Crohn Disease, Gastrointestinal Diseases, Adolescent, capsule endoscopy, Child, Colon, Colonoscopy, Early Diagnosis, Intestine, Small, young adult

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750