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23 December 2019 : Animal Research  

Antidiabetic and Hypolipidemic Effects of 5,7-Dimethoxyflavone in Streptozotocin-Induced Diabetic Rats

Yongli Xie1ABCDEFG*, Yawei Zhang1ABCDE, Xiaoqing Su1BCDE

DOI: 10.12659/MSM.918794

Med Sci Monit 2019; 25:9893-9901

Abstract

BACKGROUND: The flavones are considered as competent antidiabetic molecules due to their strong antioxidant activities and higher in vivo stability. The present study evaluated the antidiabetic and hypolipidemic effects of 5,7-dimethoxyflavone in streptozotocin (STZ)-induced diabetic rat models.

MATERIAL AND METHODS: The antidiabetic potential of 5,7-dimethoxyflavone was evaluated in streptozotocin-induced diabetic rats. The serum levels of triglyceride, total cholesterol, and high-density lipoprotein cholesterol were measured using the Randox assay kit. Histopathological examination was carried out by hematoxylin and eosin (HE) staining.

RESULTS: Oral administration of 5,7-dimethoxyflavone significantly reduced STZ-induced enhancement in blood sugar and glycosylated hemoglobin, as well as significant increases in C-peptide, insulin, hemoglobin, and total protein content (p<0.05). Additionally, treatment with 5,7-dimethoxyflavone resulted in a remarkable increase in non-enzymic antioxidants. Administration of 5,7-dimethoxyflavone had a hypolipidemic effect by significantly reducing levels of serum triglycerides, total cholesterol, and low-density lipoproteins. The histopathological examination of rat pancreases revealed the beneficial effect of 5,7-dimethoxyflavone and protection of β cell integrity in STZ-induced diabetic rats.

CONCLUSIONS: These findings reflect the antidiabetic and hypolipidemic effects of 5,7-dimethoxyflavone, suggesting that 5,7-dimethoxyflavone may be a promising compound for use in development of new antidiabetic drugs.

Keywords: Diabetes Mellitus, Type 1, Flavones, Hypoglycemic Agents, Antioxidants, Blood Glucose, Diabetes Mellitus, Experimental, Flavonoids, Glycated Hemoglobin A, Hypolipidemic Agents, Insulin, Lipids, Liver, Rats, Wistar, Streptozocin

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750