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19 December 2019 : Animal Research  

Multifunctional Polyethylene Glycol (PEG)-Poly (Lactic-Co-Glycolic Acid) (PLGA)-Based Nanoparticles Loading Doxorubicin and Tetrahydrocurcumin for Combined Chemoradiotherapy of Glioma

Xingzhen Zhang12ABCDEF, Lixia Zhao12AEFG, Guangxi Zhai2AD, Jianbo Ji2B, Anchang Liu12AFG*

DOI: 10.12659/MSM.918899

Med Sci Monit 2019; 25:9737-9751

Abstract

BACKGROUND: This study aimed to prepare doxorubicin- and tetrahydrocurcumin-loaded and transferrin-modified PEG-PLGA nanoparticles (Tf-NPs-DOX-THC) for enhanced and synergistic chemoradiotherapy.

MATERIAL AND METHODS: Tf-NPs-DOX-THC were prepared via the double-emulsion method. The morphologies and particle sizes of the prepared nanoparticles were examined by TEM and DLS, respectively. The in vitro MTT, apoptosis, and clone formation assays were performed to detect the proliferation and radiosensitivity of cells with various treatments. Cellular uptake assay was also conducted. The tissue distribution of Tf-NPs was investigated by ex vivo DOX fluorescence imaging. The in vivo tumor growth inhibition efficiency of various treatments was evaluated in orthotopic C6 mouse models and C6 subcutaneously grafted mouse models.

RESULTS: Tf-NPs-DOX-THC exhibited high drug-loading efficiency (6.56±0.32%) and desirable particle size (under 250 nm). MTT, apoptosis, and clone formation assays revealed the enhanced anti-cancer activity and favorable radiosensitizing effect of Tf-NPs-DOX-THC. Strong fluorescence was observed in the brains of mice treated with Tf-NPs-DOX. The in vitro release of drug from nanoparticles was in a pH-sensitive manner. Tf-NPs-DOX-THC in combination with radiation also achieved favorable anti-tumor efficacy in vivo.

CONCLUSIONS: All results suggest that a combination of Tf-NPs-DOX-THC and radiation is a promising strategy for synergistic and sensitizing chemoradiotherapy of glioma.

Keywords: chemoradiotherapy, Nanoparticles, Receptors, Transferrin, Curcumin, Drug Carriers, Drug Delivery Systems, Emulsions, Glioma, Lactates, Particle Size, Polyesters, Polyethylene Glycols, Tissue Distribution, Transferrin

Errate

Med Sci Monit 2020; 26:e926333     https://medscimonit.com/abstract/index/idArt/926333

The authors informed the journal that an error occurred in their manuscript.
Figure 2D was mistakenly overlooked by the authors during the galley proof stage.
Reference:
1. Zhang X, Zhao L, Zhai G, Ji J, Liu A. Multifunctional Polyethylene Glycol (PEG)-Poly (Lactic-Co-Glycolic Acid) (PLGA)-Based Nanoparticles Loading Doxorubicin and Tetrahydrocurcumin for Combined Chemoradiotherapy of Glioma. Med Sci Monit, 2019; 25: 9737–9751.
doi: 10.12659/MSM.918899
 
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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750