25 October 2019 : Animal Research
A Pilot Study of Third-Generation Dual-Source Computed Tomography for the Assessment of Global Dynamic Changes in Left Ventricular Structure and Function in a Porcine Model of Acute Myocardial InfarctionWenjia Li12CEG, Liang Lyu2A, Weixin Yang2B, Rongshun Zhang3B, Gang Wang2F, Dong Fang2D, Wei Song2C, Junkun Yin2B, Jiangmao Yang2B, Wei Li2B, Liling Chen4B, Tianyou Luo5A*
Med Sci Monit 2019; 25:7989-7997
BACKGROUND: First-generation and second-generation dual-source computed tomography (DSCT) are useful for analyzing left ventricle (LV) structure and function. This pilot study aimed to investigate the feasibility and role of third-generation DSCT for the evaluation of dynamic changes in LV structural and functional characteristics in a Diannan small-ear pig model of acute myocardial infarction (AMI).
MATERIAL AND METHODS: The model of AMI was established by balloon occlusion of the distal third of the left anterior descending (LAD) coronary artery in 14 Diannan small-eared pigs. Third-generation DSCT was performed to observe dynamic changes in LV structure and function before and after AMI was induced, with a follow-up period of 30 days.
RESULTS: The mean structural measurements at baseline included interventricular septum thickness (8.50±0.90 mm), LV anterior wall thickness (8.40±1.30 mm), LV posterior wall thickness (7.80±1.20 mm), LV end-diastolic dimension (LVEDD) (45.00±4.90 mm), and LV end-systolic dimension (LVESD) (25.90±4.10 mm). The mean functional measurements at baseline included the LV end-diastolic volume (LVEDV) (74.62±13.54 ml), LV end-systolic volume (LVESV) (23.06±7.46 ml), LV ejection fraction (LVEF) (69.29±6.83%), LV mass (86.35±14.02 g), stroke volume (SV) (51.56±9.77 ml), and cardiac output (CO) (4.22±2.14 l/min). Trends of time-dependent changes were observed for LVESV, LVEF, SV, and CO, but not for LVEDV or LV mass.
CONCLUSIONS: Third-generation DSCT was validated as a tool for assessing dynamic changes in LV global function in a porcine model of AMI.
Keywords: Coronary Artery Disease, multidetector computed tomography, Swine, Ventricular Function, Left, Cardiac Output, Heart Ventricles, Myocardial Infarction, Pilot Projects, Stroke Volume, Tomography, X-Ray Computed
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