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27 February 2020 : Clinical Research  

Association of Obesity Measures with Atrial Fibrillation Recurrence After Cryoablation in Patients with Paroxysmal Atrial Fibrillation

Luxiang Shang12BCDEF, Mengjiao Shao12BCDEF, Qilong Guo12BE, Jiasuoer Xiaokereti12BE, Yang Zhao12BE, Yanmei Lu12CDE, Ling Zhang23CDE, Baopeng Tang12AG*, Xianhui Zhou12AG

DOI: 10.12659/MSM.920429

Med Sci Monit 2020; 26:e920429


BACKGROUND: Obesity increases the risk of atrial fibrillation (AF) recurrence after ablation. This study explored the relationship between various obesity indexes and risk of recurrence after cryoablation of paroxysmal AF (PAF).

MATERIAL AND METHODS: Our prospective study included 100 patients with PAF who underwent first cryoablation. Physical examination and fasting blood lipids levels were measured at baseline. Seven obesity indexes were determined: body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), waist-hip ratio (WHR), cardiometabolic index (CMI), lipid accumulation product (LAP), and body adiposity index (BAI). AF recurrence was confirmed by electrocardiograms and Holter monitor at follow-up visits after the initial 3-month blanking period. Receiver operating characteristic (ROC) curves were drawn to assess the abilities of obesity indicators in predicting AF recurrence. Multivariable Cox regression analysis was used to examine independent predictors of AF recurrence.

RESULTS: During a mean follow-up of 13.4 months, 31 patients (31.0%) had recurrent AF. Patients with recurrence had higher BMI, WC, WHtR, LAP, and BAI compared with those without recurrence. ROC analysis indicated the potential predictive value of BAI with an AUC of 0.657 (95% confidence interval [CI]: 0.534–0.779), followed by WC, WHtR, LAP, and BMI (all P<0.05). Diagnosis-to-ablation time (HR 1.034, 95% CI: 1.002–1.068), left atrial diameter (HR 1.147, 95% CI: 1.026–1.281), and WC (HR 1.026, 95% CI: 1.000–1.053) were independent predictive factors for AF recurrence after multivariable adjustment.

CONCLUSIONS: In this study population, WC appears to be a potential indicator for the prediction of recurrence in patients with PAF after cryoablation.

Keywords: Atrial Fibrillation, Body Mass Index, Obesity, Recurrence, waist circumference, Adiposity, Aged, China, Cryosurgery, Middle Aged, Prospective Studies, ROC Curve, Risk Factors, Waist-Height Ratio, Waist-Hip Ratio



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Editorial: Rebound COVID-19 and Cessation of Antiviral Treatment for SARS-CoV-2 with Paxlovid and Molnupiravir

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.938532

Med Sci Monit 2022; 28:e938532


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750