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09 March 2020 : Clinical Research  

Incidence and Risk Factors for Suicide Death among Kaposi’s Sarcoma Patients: A Surveillance, Epidemiology, and End Results Analysis

Jian Shen12ABCDE, Mingjian Zhu12CDF, Sihao Li3DE, Qiangqiang Wang12DEF, Jingjing Wu12EF, Yating Li12EF, Qing Wang12CD, Xiaoyuan Bian12CD, Liya Yang42EF, Xianwan Jiang12EF, Jiaojiao Xie12CD, Yanmeng Lu12CD, Kaiceng Wang12EF, Lanjuan Li12AEG*

DOI: 10.12659/MSM.920711

Med Sci Monit 2020; 26:e920711


BACKGROUND: The suicide risk of patients with cancer is higher than the general population. Our research aimed to explore the Surveillance, Epidemiology, and End Results (SEER) database to define incidence and quest risk factors for death of suicide in patients with Kaposi’s sarcoma (KS) in the United States (US).

MATERIAL AND METHODS: We screened KS patients without human immunodeficiency virus status in the SEER database from 1980 to 2016, calculated the standardized mortality ratios of them by comparing the rates with those of the US general population from 1980 to 2016, and identified relevant suicide risk factors by univariable and multivariable logistic regression analyses.

RESULTS: The suicide rates of KS patients and US general population were 115.31 (110 suicides among 21 405 patients) and 15.1 per 100 000 person-years, respectively, thus the standardized mortality ratio was 7.64 (95% confidence interval [CI], 6.28–9.21). The multivariate analysis showed that black race (versus white race, hazard ratio [HR]: 0.43, 95% CI: 0.21–0.89, P=0.022), advanced age at diagnosis (≥55 years versus 18–44 years, HR: 0.31, 95% CI: 0.14–0.66, P=0.002), and chemotherapy (versus no chemotherapy, HR: 0.60, 95% CI: 0.37–0.96, P=0.032) were protective factors for suicide among KS patients.

CONCLUSIONS: Clinicians and caregivers can apply our findings to identify KS patients with high suicide risk characteristics (white race, age of 18-44 years, non-chemotherapy) and exert timely interventions during patient diagnosis, treatment, and follow-up to reduce the suicide rate in this population.

Keywords: Risk Factors, Sarcoma, Kaposi, SEER Program, Suicide, Adolescent, Age Factors, Incidence, United States, Whites, young adult

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Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750