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Latest Articles

#944243

25 Jul 2024 : Clinical Research  

Olfactory Dysfunction as a Marker for Cognitive Impairment in General Paresis of the Insane: A Clinical Study

Shuang Liang, Ben Chen [...]

DOI: 10.12659/MSM.944243

Med Sci Monit 2024; 30:e944243

#944243

25 Jul 2024 : Clinical Research  

Olfactory Dysfunction as a Marker for Cognitive Impairment in General Paresis of the Insane: A Clinical Study

Shuang Liang, Ben Chen [...]

DOI: 10.12659/MSM.944243

Med Sci Monit 2024; 30:e944243

#943975

24 Jul 2024 : Clinical Research  

Ultrasound-Guided PRP and SVF Therapy Shows Sustained Improvement in Severe Knee Osteoarthritis: A 12-Month Retrospective Study

Savas Comlek ORCID logo, Dilek Baykal ORCID logo [...]

DOI: 10.12659/MSM.943975

Med Sci Monit 2024; 30:e943975

#943975

24 Jul 2024 : Clinical Research  

Ultrasound-Guided PRP and SVF Therapy Shows Sustained Improvement in Severe Knee Osteoarthritis: A 12-Month Retrospective Study

Savas Comlek ORCID logo, Dilek Baykal ORCID logo [...]

DOI: 10.12659/MSM.943975

Med Sci Monit 2024; 30:e943975

#943617

24 Jul 2024 : Review article  

Optimizing Quality of Life in Kidney Transplant Recipients Through Structured Exercise: A Systematic Review and Evidence-Based Guidelines

Wushi Wang,

DOI: 10.12659/MSM.943617

Med Sci Monit 2024; 30:e943617

#943617

24 Jul 2024 : Review article  

Optimizing Quality of Life in Kidney Transplant Recipients Through Structured Exercise: A Systematic Review and Evidence-Based Guidelines

Wushi Wang,

DOI: 10.12659/MSM.943617

Med Sci Monit 2024; 30:e943617

#944727

23 Jul 2024 : Database Analysis  

Trends in HIV/AIDS-Related Mortality and the Impact of Antiretroviral Treatment Strategies in Lu'an City: A Comprehensive Analysis

Rui Shu, Haili Lyu [...]

DOI: 10.12659/MSM.944727

Med Sci Monit 2024; 30:e944727

#944727

23 Jul 2024 : Database Analysis  

Trends in HIV/AIDS-Related Mortality and the Impact of Antiretroviral Treatment Strategies in Lu'an City: A Comprehensive Analysis

Rui Shu, Haili Lyu [...]

DOI: 10.12659/MSM.944727

Med Sci Monit 2024; 30:e944727

#944383

23 Jul 2024 : Database Analysis  

Enhanced Outcomes in Femoral Subtrochanteric Fractures Using Long INTERTAN Nails with Titanium Cable Cerclage: A Retrospective Analysis

Mingjian Bei, Yaping Xiao [...]

DOI: 10.12659/MSM.944383

Med Sci Monit 2024; 30:e944383

#944383

23 Jul 2024 : Database Analysis  

Enhanced Outcomes in Femoral Subtrochanteric Fractures Using Long INTERTAN Nails with Titanium Cable Cerclage: A Retrospective Analysis

Mingjian Bei, Yaping Xiao [...]

DOI: 10.12659/MSM.944383

Med Sci Monit 2024; 30:e944383

0:00
#944297

22 Jul 2024 : Clinical Research  

Reduced Radial Artery Occlusion in Transradial Cerebral Angiography: Key Predictive Factors and Preventive Measures from a Single-Center Study of 543 Patients

Wu Jian, Ranze Cai [...]

DOI: 10.12659/MSM.944297

Med Sci Monit 2024; 30:e944297

#944297

22 Jul 2024 : Clinical Research  

Reduced Radial Artery Occlusion in Transradial Cerebral Angiography: Key Predictive Factors and Preventive Measures from a Single-Center Study of 543 Patients

Wu Jian, Ranze Cai [...]

DOI: 10.12659/MSM.944297

Med Sci Monit 2024; 30:e944297

0:00
#944985

22 Jul 2024 : Clinical Research  

Comparative Analysis of Antihypertensive and Anticonvulsant Regimens in Managing Pre-eclampsia and Eclampsia: Insights from a Sudanese Retrospective Study

Qusay O. Abdalla ORCID logo, Esraa O. Mohammed ORCID logo [...]

DOI: 10.12659/MSM.944985

Med Sci Monit 2024; 30:e944985

#944985

22 Jul 2024 : Clinical Research  

Comparative Analysis of Antihypertensive and Anticonvulsant Regimens in Managing Pre-eclampsia and Eclampsia: Insights from a Sudanese Retrospective Study

Qusay O. Abdalla ORCID logo, Esraa O. Mohammed ORCID logo [...]

DOI: 10.12659/MSM.944985

Med Sci Monit 2024; 30:e944985

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#944526

21 Jul 2024 : Clinical Research  

Cost-Effectiveness Analysis of Hepatic Arterial Chemotherapy for Advanced Hepatocellular Carcinoma in China: A Comparative Analysis of HAIC-FO and Sorafenib

Jie Gao, Shu Liu [...]

DOI: 10.12659/MSM.944526

Med Sci Monit 2024; 30:e944526

#944526

21 Jul 2024 : Clinical Research  

Cost-Effectiveness Analysis of Hepatic Arterial Chemotherapy for Advanced Hepatocellular Carcinoma in China: A Comparative Analysis of HAIC-FO and Sorafenib

Jie Gao, Shu Liu [...]

DOI: 10.12659/MSM.944526

Med Sci Monit 2024; 30:e944526

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#944810

20 Jul 2024 : Clinical Research  

Frontal Plane Body Posture as a Predictor of Musculoskeletal Injuries in Amateur Athletes: A Comprehensive Study of 89 Participants Over 12 Months

Katarzyna Kochan-Jacheć, Dawid Koźlenia ORCID logo [...]

DOI: 10.12659/MSM.944810

Med Sci Monit 2024; 30:e944810

#944810

20 Jul 2024 : Clinical Research  

Frontal Plane Body Posture as a Predictor of Musculoskeletal Injuries in Amateur Athletes: A Comprehensive Study of 89 Participants Over 12 Months

Katarzyna Kochan-Jacheć, Dawid Koźlenia ORCID logo [...]

DOI: 10.12659/MSM.944810

Med Sci Monit 2024; 30:e944810

0:00
#943176

19 Jul 2024 : Clinical Research  

Minimally Invasive versus Traditional Surgery: Efficacy of PELD and PLIF in Treating Pyogenic Spondylodiscitis

Yuan Liu, Tianlong Wu [...]

DOI: 10.12659/MSM.943176

Med Sci Monit 2024; 30:e943176

#943176

19 Jul 2024 : Clinical Research  

Minimally Invasive versus Traditional Surgery: Efficacy of PELD and PLIF in Treating Pyogenic Spondylodiscitis

Yuan Liu, Tianlong Wu [...]

DOI: 10.12659/MSM.943176

Med Sci Monit 2024; 30:e943176

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#944682

18 Jul 2024 : Clinical Research  

Impact of Denture Use on Oral Health-Related Quality of Life in Yemeni Patients: A Cross-Sectional Analysis

Nadhra N. Alalwani ORCID logo, Abbas Mohammed Al-Kebsi [...]

DOI: 10.12659/MSM.944682

Med Sci Monit 2024; 30:e944682

#944682

18 Jul 2024 : Clinical Research  

Impact of Denture Use on Oral Health-Related Quality of Life in Yemeni Patients: A Cross-Sectional Analysis

Nadhra N. Alalwani ORCID logo, Abbas Mohammed Al-Kebsi [...]

DOI: 10.12659/MSM.944682

Med Sci Monit 2024; 30:e944682

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#943170

17 Jul 2024 : Clinical Research  

Prognostic Impact of Tumor-Infiltrating Immune Cells on Efficacy of Neoadjuvant Chemotherapy in Patients with Advanced or Metastatic Ovarian Cancer: A Retrospective Study

Qunxian Rao, Miaoling Huang [...]

DOI: 10.12659/MSM.943170

Med Sci Monit 2024; 30:e943170

#943170

17 Jul 2024 : Clinical Research  

Prognostic Impact of Tumor-Infiltrating Immune Cells on Efficacy of Neoadjuvant Chemotherapy in Patients with Advanced or Metastatic Ovarian Cancer: A Retrospective Study

Qunxian Rao, Miaoling Huang [...]

DOI: 10.12659/MSM.943170

Med Sci Monit 2024; 30:e943170

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#944645

17 Jul 2024 : Clinical Research  

Effects of Ozone Disc Nucleolysis in Management of Herniated Lumbar Intervertebral Disc: A Retrospective Single-Center Study of 149 Patients

Ibrahim Burak Atcı, Okan Turk [...]

DOI: 10.12659/MSM.944645

Med Sci Monit 2024; 30:e944645

#944645

17 Jul 2024 : Clinical Research  

Effects of Ozone Disc Nucleolysis in Management of Herniated Lumbar Intervertebral Disc: A Retrospective Single-Center Study of 149 Patients

Ibrahim Burak Atcı, Okan Turk [...]

DOI: 10.12659/MSM.944645

Med Sci Monit 2024; 30:e944645

0:00

Editorial

01 July 2024 : Editorial  

Editorial: The Global Threats of Increasing Antimicrobial Resistance Require New Approaches to Drug Development, Including Molecular Antimicrobial Adjuvants

Dinah V. Parums

DOI: 10.12659/MSM.945583

Med Sci Monit 2024; 30:e945583

0:00

In Press

Clinical Research  

Endoscopic and Microscopic Tympanoplasty for Adhesive Otitis Media: A Comparative Prospective Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.945152  

Clinical Research  

Status of Professional Identity, Self-Directed Learning Competence, and Self-Efficacy Among Central Sterile...

Med Sci Monit In Press; DOI: 10.12659/MSM.944044  

Clinical Research  

Enhanced Postoperative Pain Management and Mobility Following Arthroscopic Knee Surgery: A Comparative Stud...

Med Sci Monit In Press; DOI: 10.12659/MSM.943735  

Database Analysis  

Impact of Standing and Sitting Postures on Spinal Curvature and Muscle Mechanical Properties in Young Women...

Med Sci Monit In Press; DOI: 10.12659/MSM.944930  

Most Viewed Current Articles

17 Jan 2024 : Review article   4,548,690

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,606,306

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   691,121

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial   50,927

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750
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12 February 2020 : Animal Research  

Integrative Analysis of Long Non-Coding RNAs (lncRNAs), miRNAs, and mRNA-Associated ceRNA Network in Lung Tissue of Aging Mice and Changes After Treatment with Codonopsis pilosula

Dongmei Chen1CDE, Jiajia Liu1B, Jie Meng1F, Dandan Li1B, Pan Zhao1F, Yongqiang Duan2D, Jing Wang13AEG*

DOI: 10.12659/MSM.921580

Med Sci Monit 2020; 26:e921580

Abstract

BACKGROUND: Codonopsis pilosula is a traditional Chinese medicine that has an anti-aging effect. However, the anti-aging effect of Codonopsis pilosula on the lungs remains largely unknown, and the molecular mechanism also needs to be further studied. Thus, we investigated the protective effect of Codonopsis pilosula on the lungs of aging mice, and explored the underlying molecular mechanism.

MATERIAL AND METHODS: We established an aging mouse model and then treated the mice with Codonopsis pilosula. Microarray analysis and bioinformatics methods were used to comprehensively analyze the lncRNA-miRNA-mRNA (ceRNA) network.

RESULTS: Our results showed that we successfully established the aging mouse model. The microarray analysis showed that 138 lncRNAs, 128 mRNAs, and 7 miRNAs were significantly changed after aging, and 282 lncRNAs, 283 mRNAs, and 19 miRNAs were dysregulated after treatment with Codonopsis pilosula. To explore the signaling pathways involved, KEGG pathway analysis was performed. Compared with the ceRNA network in aging mice and after treatment with Codonopsis pilosula, we found that 3 mRNAs (Hif3a, Zbtb16, Plxna2) and 1 lncRNA (NONMMUT063872) were associated with the anti-aging effect of Codonopsis pilosula and they were validated by quantitative real-time polymerase chain reaction (qRT-PCR) analysis.

CONCLUSIONS: Our results showed that Codonopsis pilosula has a protective effect on the aging lung, and the ceRNA network plays an important role in the anti-aging effect of Codonopsis pilosula.

Keywords: Aging, Codonopsis, Lung Diseases, Microarray Analysis, Computational Biology, Drugs, Chinese Herbal, Gene Regulatory Networks, Models, Animal, RNA, Messenger, Specific Pathogen-Free Organisms

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Editorial

01 December 2024 : Editorial  

Editorial: The 2024 Revision of the Declaration of Helsinki and its Continued Role as a Code of Ethics to Guide Medical Research

Dinah V. Parums

DOI: 10.12659/MSM.947428

Med Sci Monit 2024; 30:e947428

0:00

In Press

Clinical Research  

Evaluating Lipiodol Efficacy in Proximal Tubal Occlusion Treatment: Single-Center Experience and Literature...

Med Sci Monit In Press; DOI: 10.12659/MSM.946266  

Review article  

Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Re...

Med Sci Monit In Press; DOI: 10.12659/MSM.945147  

Meta-Analysis  

Reliability of Extraoral Scanners in Capturing 3D Geometry for Dental Prostheses: A Systematic Review

Med Sci Monit In Press; DOI: 10.12659/MSM.946470  

Review article  

Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic Approaches

Med Sci Monit In Press; DOI: 10.12659/MSM.945336  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,957,034

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,969,335

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   697,010

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

07 Jan 2022 : Meta-Analysis   263,050

Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...

DOI :10.12659/MSM.935074

Med Sci Monit 2022; 28:e935074

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750