27 May 2020 : Clinical Research
Using Cutaneous Receptor Vibration to Uncover the Effect of Transcranial Magnetic Stimulation (TMS) on Motor Cortical ExcitabilityMaja Rogić Vidaković1ABCDEF*, Ana Kostović1BD, Ana Jerković1CDE, Joško Šoda2CDE, Mladen Russo3C, Maja Stella3C, Ante Knežić3AF, Igor Vujović2CDE, Mario Mihalj4DEF, Jure Baban5A, Davor Ljubenkov6A, Marin Peko3A, Benjamin Benzon1BD, Maximilian Vincent Hagelien1D, Zoran Đogaš1ADFG
Med Sci Monit 2020; 26:e923166
BACKGROUND: Little is known about how vibrational stimuli applied to hand digits affect motor cortical excitability. The present transcranial magnetic stimulation (TMS) study investigated motor evoked potentials (MEPs) in the upper extremity muscle following high-frequency vibratory digit stimulation.
MATERIAL AND METHODS: High-frequency vibration was applied to the upper extremity digit II utilizing a miniature electromagnetic solenoid-type stimulator-tactor in 11 healthy study participants. The conditioning stimulation (C) preceded the test magnetic stimulation (T) by inter-stimulus intervals (ISIs) of 5–500 ms in 2 experimental sessions. The TMS was applied over the primary motor cortex for the hand abductor pollicis-brevis (APB) muscle.
RESULTS: Dunnett’s multiple comparisons test indicated significant suppression of MEP amplitudes at ISIs of 200 ms (P=0.001), 300 ms (P=0.023), and 400 ms (P=0.029) compared to control.
CONCLUSIONS: MEP amplitude suppression was observed in the APB muscle at ISIs of 200–400 ms, applying afferent signaling that originates in skin receptors following the vibratory stimuli. The study provides novel insight on the time course and MEP modulation following cutaneous receptor vibration of the hand digit. The results of the study may have implications in neurology in the neurorehabilitation of patients with increased amplitude of MEPs.
Keywords: Evoked Potentials, Motor, Pacinian Corpuscles, Transcranial Magnetic Stimulation, Vibration, cortical excitability, Electric Stimulation, Fingers, Hand, healthy volunteers, Middle Aged, Motor Cortex, Muscle, Skeletal
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