13 April 2016 : Clinical Research
Evaluation of Maternal Serum 25-Hydroxyvitamin D, Paraoxonase 1 Levels, and Neutrophil-to-Lymphocyte Ratio in Spontaneous Preterm Birth
Ozlem Bozoklu AkkarABCDEFG, Enver SancakdarA, Savas KarakusB, Caglar YildizB, Ismail AkkarE, Murat ArslanB, Irfan Oguz SahinD, Ayse Gonca Imir YenicesuF, Ali CetinCEFDOI: 10.12659/MSM.897983
Med Sci Monit 2016; 22:1238-1243
Abstract
BACKGROUND: The aim of this study was to evaluate the association of maternal serum 25-hydroxyvitamin D, paraoxonase 1, and neutrophil-to-lymphocyte ratio in women having early spontaneous preterm birth without clinical chorioamnionitis.
MATERIAL AND METHODS: This study was prospectively administered in women referred to our obstetrics service with preterm labor that resulted in preterm birth (n=35) and term labor that ended in term birth (n=44). The maternal serum levels of 25-hydroxyvitamin D and paraoxonase 1 were measured and neutrophil-to-lymphocyte ratio was calculated.
RESULTS: The 25-hydroxyvitamin D and paraoxonase 1 levels of the preterm group were significantly lower than those of the term group (p<0.05). The neutrophil-to-lymphocyte ratio value of the preterm group was significantly higher than that of the term group (p<0.05). There was a significant but small positive correlation between the serum levels of 25-hydroxyvitamin D and paraoxonase 1 in the preterm group (r=0.35; p=0.021).
CONCLUSIONS: Decreased maternal serum 25-hydroxyvitamin D and paraoxonase 1 levels and increased neutrophil-to-lymphocyte ratio may have a role in the etiology of spontaneous preterm birth.
Keywords: Aryldialkylphosphatase - blood, Biomarkers - blood, Lymphocytes - metabolism, Neutrophils - metabolism, Obstetric Labor, Premature - blood, Pregnancy, Premature Birth - blood, Vitamin D - blood
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