Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 April 2004

Dietary supplementation with olive oil leads to improved lipoprotein spectrum and lower n-6 PUFAs in elderly subjects

Peter Haban, Jana Klvanova, Eva Zidekova, Anna Nagyova

Med Sci Monit 2004; 10(4): PI49-54 :: ID: 11621

Abstract

Background:Oleic acid, polyphenols, and other components abundantly present in olive oil are thought to be partly responsible for the antiatherogenic effects attributed to the Mediterranean diet. One of the expected outcomes is a positive impact on the lipoprotein spectrum, but also other benefits are to be expected.Material/Methods: The analysis was conducted on 28 outpatients older than 50 years of age (mean age 68.1, 95%CI 64.9–71.3). The supplement was taken for 6 weeks and involved daily consumption of 2 tablespoons (approx. 20 g) of extra-virgin olive oil as part of the subjects’ habitual diets, without changing their usual total energy and fat consumption. This phase was followed by a 2-month wash-out.Results: After dietary supplementation with olive oil, serum total- and LDL-cholesterol mean concentrations were lowered by 0.818 mmol/l (p<0.00002; 95% CI –1.142 to –0.493 mmol/l) and 0.782 mmol/l (p=0.00013; 95% CI –1.141 to –0.423 mmol/l), respectively. There was also a significant decline in the total-to-HDL and LDL-to-HDL cholesterol ratios (p<0.03 and p<0.015). Linolic and arachidonic acid content in serum phospholipids decreased significantly (p<0.01 and p<0.001, respectively). The n-3 PUFAs were not affected.
Conclusions: These results point to an overwhelmingly beneficial influence of olive oil on the lipoprotein spectrum. The statistically significant reduction in arachidonic acid may even be regarded as clinically desirable. An excellent complementarity between the effects of MUFAs and long-chain n-3 PUFAs is to be expected.

Keywords: Arachidonic Acid, Cholesterol - blood, Dietary Supplements, Fatty Acids, Unsaturated - blood, Hypercholesterolemia - blood, Hypercholesterolemia - diet therapy, Lipids - blood, Oleic Acid - pharmacology, Plant Oils - pharmacology, Triglycerides - blood, Arachidonic Acid, Cholesterol - blood, Dietary Supplements, Fatty Acids, Unsaturated - blood, Hypercholesterolemia - diet therapy, Lipids - blood, Oleic Acid - pharmacology, Plant Oils - pharmacology, Triglycerides - blood

0 Comments

Editorial

04 June 2022 : Editorial  

Editorial: Acute Hepatitis of Unknown Origin in Children. Is Autoimmunity at Play?

Nahum Mendez-Sanchez, Shreya C. Pal
Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico

DOI: 10.12659/MSM.937371

Med Sci Monit 2022; 28:e937371

SARS-CoV-2/COVID-19

30 June 2022 : Editorial  

Editorial: World Health Organization (WHO) Variants of Concern Lineages Under Monitoring (VOC-LUM) in Respo...

Med Sci Monit In Press; DOI: 10.12659/MSM.937676  

27 June 2022 : Clinical Research  

Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...

Med Sci Monit In Press; DOI: 10.12659/MSM.937430  

In Press

30 Jun 2022 : Laboratory Research  

Bcl-2 19-kDa Interacting Protein 3 (BNIP3)-Mediated Mitophagy Attenuates Intermittent Hypoxia-Induced Human...

Med Sci Monit In Press; DOI: 10.12659/MSM.936760  

30 Jun 2022 : Editorial  

Editorial: World Health Organization (WHO) Variants of Concern Lineages Under Monitoring (VOC-LUM) in Respo...

Med Sci Monit In Press; DOI: 10.12659/MSM.937676  

30 Jun 2022 : Clinical Research  

Antioxidant System and Ions Concentrations After Femoral Neck and Resurfacing Hip Arthroplasty

Med Sci Monit In Press; DOI: 10.12659/MSM.936335  

28 Jun 2022 : Meta-Analysis  

Urodynamics in Early Diagnosis of Diabetic Bladder Dysfunction in Women: A Systematic Review and Meta-Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.937166  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750