01 February 2005
Ceruloplasmin - acute-phase reactant or endogenous antioxidant? The case of cardiovascular disease.
Natalia Giurgea, Mihaela Ioana Constantinescu, Ramona Stanciu, Soimita Suciu, Adriana MuresanMed Sci Monit 2005; 11(2): RA48-51 :: ID: 14230
Abstract
Ceruloplasmin is a plasma protein that functions as a copper transporter. Epidemiological studies have indicated an association between the concentration of this protein and risk for cardiovascular disease. The mechanism for the involvement of ceruloplasmin in cardiovascular disease and other conditions is not yet clear, although it is widely accepted that the role played by ceruloplasmin in facilitating or counteracting oxidative stress is central. We review here some of the studies on this issue and try to calm down the duel between the claims supporting the oxidant or the antioxidant effects of ceruloplasmin through a clear-cut analysis of the available data. Our conclusion is that a verdict regarding the pathogenetic involvement of ceruloplasmin in cardiovascular disease should await further research.
Keywords: Acute-Phase Reaction, Antioxidants - metabolism, Cardiovascular Diseases - metabolism, Ceruloplasmin - chemistry, Ceruloplasmin - metabolism, Lipoproteins - metabolism, Acute-Phase Reaction, Antioxidants - metabolism, Cardiovascular Diseases - metabolism, Ceruloplasmin - metabolism, Lipoproteins - metabolism
Editorial
01 January 2023 : Editorial
Editorial: Current Status of Two Adjuvanted Malaria Vaccines and the World Health Organization (WHO) Strategy to Eradicate Malaria by 2030DOI: 10.12659/MSM.939357
Med Sci Monit 2023; 29:e939357
SARS-CoV-2/COVID-19
19 January 2023 : Clinical Research
Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...Med Sci Monit In Press; DOI: 10.12659/MSM.938892
19 January 2023 : Clinical Research
Determining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical Research
Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...Med Sci Monit 2022; 28:e938926
10 December 2022 : Clinical Research
Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...Med Sci Monit 2022; 28:e938647
In Press
20 Jan 2023 : Clinical Research
A Study of 42 Partially Edentulous Patients with Single-Crown Restorations and Implants to Compare Bone Los...Med Sci Monit In Press; DOI: 10.12659/MSM.939225
20 Jan 2023 : Clinical Research
Perfusate Neutrophil Gelatinase-Associated Lipocalin, Kidney Injury Molecular-1, Liver-Type Fatty Acid Bind...Med Sci Monit In Press; DOI: 10.12659/MSM.938758
19 Jan 2023 : Clinical Research
Bakri Balloon for Treatment of Postpartum Hemorrhage: A Real-World 2016-2020 Study in 279 Women from a Sing...Med Sci Monit In Press; DOI: 10.12659/MSM.938823
19 Jan 2023 : Clinical Research
Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...Med Sci Monit In Press; DOI: 10.12659/MSM.938892
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952