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01 September 1997

Influence of 5,7-dihydroxytryptamine (5,7-DHT) on the antinociceptive effect of serotonine (5-HT) 5-HT2c receptor agonist in male and female rats

Ryszard Brus, Alicja Kasperska, Joanna Oświęcimska, Ryszard Szkilnik

Med Sci Monit 1997; 3(5): BR654-656 :: ID: 501536

Abstract

Male and female 3 day old Wistar rats were injected intracerebroventricularly with 5,7-dyhydroxytryptamine (ICV) 50 µg in order to destroy the central serotonine (5-HT) system. When the animals attained the age of about 3 months the antinociceptive effect of mCPP, a central 5-HT2C, receptor agonist, was examined using hot plate test. The levels of 5-HT and its metabolite 5-HIAA were estimated in the striatum. Our results support findings of other authors, that the central 5-HT2C, receptor is involved in the nociceptive action of mCPP and the above mentioned effect is dependent on an intact central 5-HT system (in female rats only).

Keywords: male and female rats, 5,7-Dihydroxytryptamine, mCPP, Hot plate

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750