01 September 1997
Influence of 5,7-dihydroxytryptamine (5,7-DHT) on the antinociceptive effect of serotonine (5-HT) 5-HT2c receptor agonist in male and female rats
Ryszard Brus, Alicja Kasperska, Joanna Oświęcimska, Ryszard SzkilnikMed Sci Monit 1997; 3(5): BR654-656 :: ID: 501536
Abstract
Male and female 3 day old Wistar rats were injected intracerebroventricularly with 5,7-dyhydroxytryptamine (ICV) 50 µg in order to destroy the central serotonine (5-HT) system. When the animals attained the age of about 3 months the antinociceptive effect of mCPP, a central 5-HT2C, receptor agonist, was examined using hot plate test. The levels of 5-HT and its metabolite 5-HIAA were estimated in the striatum. Our results support findings of other authors, that the central 5-HT2C, receptor is involved in the nociceptive action of mCPP and the above mentioned effect is dependent on an intact central 5-HT system (in female rats only).
Keywords: male and female rats, 5,7-Dihydroxytryptamine, mCPP, Hot plate
Editorial
01 August 2022 : Editorial
Editorial: Long-Term Effects of Symptomatic and Asymptomatic SARS-CoV-2 Infection in Children and the Changing Pathogenesis of Common Childhood Viruses Driven by the COVID-19 PandemicDOI: 10.12659/MSM.937927
Med Sci Monit 2022; 28:e937927
In Press
05 Aug 2022 : Clinical Research
A Retrospective Study of 98 Elderly Patients with High-Risk Lateral Femoral Wall Intertrochanteric Hip Frac...Med Sci Monit In Press; DOI: 10.12659/MSM.936923
05 Aug 2022 : Clinical Research
Hemoglobin/Red Blood Cell Distribution Width Ratio in Peripheral Blood Is Positively Associated with Progno...Med Sci Monit In Press; DOI: 10.12659/MSM.937146
04 Aug 2022 : Clinical Research
Radiological Assessment of Prevalance and Quality of Periapical Status of Endodontic TreatmentsMed Sci Monit In Press; DOI: 10.12659/MSM.936569
01 Aug 2022 : Clinical Research
Surgical Management of 48 Patients with Retrosternal Goiter and Tracheal Stenosis: A Retrospective Clinical...Med Sci Monit In Press; DOI: 10.12659/MSM.936637
Most Viewed Current Articles
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Nov 2020 : Review article
Long-Term Respiratory and Neurological Sequelae of COVID-19DOI :10.12659/MSM.928996
Med Sci Monit 2020; 26:e928996