30 December 2008
Influence of endotracheal tube bore on tidal volume during high frequency oscillatory ventilation: a model lung study
Osamu HiraoABCDEF, Naoya IguchiB, Akinori UchiyamaD, Takashi MashimoG, Masaji NishimuraG, Yuji FujinoADEFGMed Sci Monit 2009; 15(1): MT1-4 :: ID: 869508
Abstract
Background
In adults, the influence of endotracheal tube bore on tidal volume (VT) during high-frequency oscillatory ventilation (HFOV) has been little studied.
Material and Method
Via full-length 6, 7, 8, and 9 mm internal diameter (ID) endotracheal tubes (ETTs), a model lung (TTL, Michigan Instruments, MI) was ventilated using a high-frequency oscillator designed for adult patients (R100; Metran, Japan). Oscillation settings were: frequency, 5, 7, and 9 Hz; mean airway pressure, 15 cmH2O; oxygen inspiratory fraction, 0.21. At each setting: oscillator pressure swing was set at maximum; and each test combination was conducted with the model-lung compliance set at 20 and 50 mL/cmH2O. During the trials, a position sensor attached to the model-lung upper surface provided analog electrical signals for lung movement that were converted to VT evaluation data. Pressure and volume signals were digitized using an analog-to-digital converter and recorded in a computer. At each setting, three waveforms were analyzed and the average value used.
Results
At each setting, measured VT was proportional to ETT internal cross-sectional area (CSA). Regression analysis of VT showed correlation with the CSA, as expressed by formula, y=2.173x where x is CSA and y is VT (R2=0.99, p<0.001) at 5 Hz and compliance of 50 cmH2O.
Conclusions
In an adult-simulating model lung, VT during HFOV varies in proportion to ETT CSA.
Keywords: Regression Analysis, Tidal Volume - physiology, Models, Anatomic, Lung - physiology, Intubation, Intratracheal - instrumentation, High-Frequency Ventilation - methods
744 6
Editorial
01 December 2023 : Editorial
Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory InfectionsDOI: 10.12659/MSM.943312
Med Sci Monit 2023; 29:e943312
In Press
04 Dec 2023 : Animal Research
Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech...Med Sci Monit In Press; DOI:
01 Dec 2023 : Clinical Research
Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...Med Sci Monit In Press; DOI:
30 Nov 2023 : Review article
Decoding the Neurological Sequelae of General Anesthesia: A ReviewMed Sci Monit In Press; DOI:
30 Nov 2023 : Clinical Research
Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...Med Sci Monit In Press; DOI:
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292