01 December 2009
Effects of L-arginine on the Minnesota Living with Heart Failure Questionnaire quality-of-life score in patients with chronic systolic heart failure
Paolo FontaniveBDEF, Giorgio SaponatiABC, Alberto IuratoB, Cesare VolterraniB, Andrea BoniB, Laura PiccioniB, Frank L DiniABDEMed Sci Monit 2009; 15(12): CR606-611 :: ID: 878277
Abstract
Background
L-arginine, the precursor of nitric oxide, may restore nitric oxide levels and bioavailability and influence symptom severity, quality of life (QoL), physical performance, and left ventricular (LV) diastolic abnormalities in patients with chronic systolic heart failure (HF). The aim was to evaluate the effects of orally administered L-arginine in chronic HF patients.
Material and Method
A parallel double-blind multicenter randomized study was performed in 68 patients (mean age: 64+/-11 years) with mild-to-moderate systolic HF (NYHA class II-III) and LV ejection fraction (EF)
The mean difference in MLWHFQ score from baseline was -9.7 in the L-arginine (95%CI: -14.6, -4.7) and -4.2 in the placebo group (95%CI: -8.9, +0.55). The difference between groups was not statistically significant. Among the patients with advanced LV diastolic dysfunction, 7 of 9 in the L-arginine and 3 of 6 in the placebo group showed reversible restrictive mitral flow after therapy.
Conclusions
Although no significant difference in QoL score was found between L-arginine and placebo, the results showed that L-arginine significantly improved QoL from baseline, in contrast to placebo, in chronic HF patients.
Keywords: Stroke Volume - drug effects, Questionnaires, Quality of Life, Nitric Oxide - physiology, Heart Failure, Systolic - physiopathology, Exercise Test, Echocardiography, Double-Blind Method, Arginine - therapeutic use, Administration, Oral, Vasodilation - drug effects, Ventricular Dysfunction, Left - physiopathology
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952