Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

26 October 2011

Erythropoietin update 2011

Mariusz Kowalczyk, Maciej Banach, Dimitri P. Mikhailidis, Jacek Rysz

DOI: 10.12659/MSM.882037

Med Sci Monit 2011; 17(11): RA240-247

Abstract

Traditionally, erythropoietin (EPO) is described as a hematopoietic cytokine, regulating proliferation and differentiation and survival of the erythroid progenitors. The recent finding of new sites of EPO production and the wide spread distribution of EPO receptors (EPO-R) on endothelial cells, cardiomyocytes, renal cells as well as the central and peripheral nervous system raised the possibility that EPO may exert pleiotropic actions on several targets. Indeed studies (mainly preclinical) have documented protective, non-hematopoietic, abilities of EPO in a variety of tissue. However, the data obtained from clinical studies are more skeptical about these properties. This article provides a comprehensive overview of EPO and its derivatives.

Keywords: Receptors, Erythropoietin - metabolism, Neuroprotective Agents - metabolism, Neoplasms - complications, Kidney - cytology, Hypertension - chemically induced, Erythropoietin - therapeutic use, Cytoprotection - physiology, Cardiotonic Agents - metabolism, Anemia - etiology, Thrombosis - chemically induced

Add Comment 0 Comments

Editorial

01 December 2024 : Editorial  

Editorial: The 2024 Revision of the Declaration of Helsinki and its Continued Role as a Code of Ethics to Guide Medical Research

Dinah V. Parums

DOI: 10.12659/MSM.947428

Med Sci Monit 2024; 30:e947428

0:00

In Press

Clinical Research  

Comparative Efficacy of Unilateral Biportal Endoscopy vs Traditional Surgery in Lumbar Degenerative Disorders

Med Sci Monit In Press; DOI: 10.12659/MSM.946468  

Clinical Research  

Association Between Pre-Pregnancy Body Mass Index and Labor Induction Success Rates: A Case Control Study

Med Sci Monit In Press; DOI: 10.12659/MSM.946357  

Clinical Research  

Emotional Labor of Caregivers of Elderly Patients with Dementia and Disabilities in a Psychiatric Hospital ...

Med Sci Monit In Press; DOI: 10.12659/MSM.945722  

Clinical Research  

Evaluation of Perceived Stress and Its Association with Dental Caries in 290 Undergraduate Medical Students

Med Sci Monit In Press; DOI: 10.12659/MSM.946528  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,957,731

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,969,958

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   697,410

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

07 Jan 2022 : Meta-Analysis   263,374

Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...

DOI :10.12659/MSM.935074

Med Sci Monit 2022; 28:e935074

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750