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28 June 2016 : Clinical Research  

Noninvasive Cardiac Quantum Spectrum Technology Effectively Detects Myocardial Ischemia

Ke LiABCDEF, Qiao XueBCDE, Mohan LiuBCDE, Xiaoqin ZhengBCDE, Rui ChenBCDE, Yufeng LiABCE, Qing DanBCE, Danqun FangBCE

DOI: 10.12659/MSM.895480

Med Sci Monit 2016; 22:2235-2242


BACKGROUND: A standard resting electrocardiogram (ECG) shows limited sensitivity and specificity for the detection of coronary artery disease (CAD). Several analytic methods exist to enhance the sensitivity and specificity of resting ECG for diagnosis of CAD. We compared a new computer-enhanced, resting ECG analysis device, the cardiac quantum spectrum (CQS) technique, with coronary angiography in the detection of CAD.

MATERIAL AND METHODS: A consecutive sample of 93 patients with a history of suspected CAD scheduled for coronary angiography was evaluated with CQS before coronary angiography. The sensitivity and specificity of CQS and standard 12-lead ECG for detecting hemodynamically relevant coronary stenosis were compared, using coronary angiography as the reference standard. Kappa analysis was performed to assess the agreement between CQS severity scores and the level of stenosis determined by coronary angiography.

RESULTS: The CQS system identified 78 of 82 patients with hemodynamically relevant stenosis (sensitivity, 95.1%; specificity, 63.6%; accuracy, 91.4%; positive predictive value, 95.1%; negative predictive value, 63.6%). Sensitivity and accuracy were much higher for CQS analysis than for the standard ECG. The Kappa value, assessing the level of agreement between CQS and coronary angiography, was 0.376 (P<0.001).

CONCLUSIONS: CQS analysis of resting ECG data detects hemodynamically relevant CAD with high sensitivity and specificity.

Keywords: Coronary Angiography - methods, Coronary Stenosis - diagnosis, Electrocardiography - methods, Heart - physiopathology, Hemodynamics - physiology, Image Processing, Computer-Assisted - methods, Myocardial Ischemia - physiopathology, Prospective Studies



01 January 2023 : Editorial  

Editorial: Current Status of Two Adjuvanted Malaria Vaccines and the World Health Organization (WHO) Strategy to Eradicate Malaria by 2030

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939357

Med Sci Monit 2023; 29:e939357


26 January 2023 : Editorial  

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Med Sci Monit In Press; DOI: 10.12659/MSM.939580  

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Med Sci Monit 2022; 28:e938926

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Med Sci Monit In Press; DOI: 10.12659/MSM.938998  

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27 Jan 2023 : Clinical Research  

Proposal for a Simple Equation for Limb Muscle Weight Calculation

Med Sci Monit In Press; DOI: 10.12659/MSM.938606  

26 Jan 2023 : Editorial  

Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread

Med Sci Monit In Press; DOI: 10.12659/MSM.939580  

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750