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08 July 2016 : Clinical Research  

Evaluation of ICAM-1 and VCAM-1 Gene Polymorphisms in Patients with Periodontal Disease

Li WangABCDEF, Xiao-Hong LiABCDE, Wan-Chen NingABCDF

DOI: 10.12659/MSM.896979

Med Sci Monit 2016; 22:2386-2391

Abstract

BACKGROUND: We aimed to investigate the potential genetic relationships between the polymorphisms of gene rs5498 ICAM-1 and rs1041163 VCAM-1 and chronic periodontitis in a Chinese population within Heilongjiang.

MATERIAL AND METHODS: Genomic DNA was extracted from oral mucosa cells of 584 periodontal patients and 182 healthy individuals. Genotyping of the rs5498 ICAM-1 and rs1041163 VCAM-1 gene polymorphisms was performed with the Multiplex SNaPshot technique.

RESULTS: Statistically significant associations were identified between the chronic periodontal patients and the controls in the gene polymorphisms of rs5498 ICAM-1 (P=0.007) and rs1041163 VCAM-1 (P=0.029). The distribution of rs5498 (P=0.029) and rs1041163 (P=0.049) differed significantly across the mild, moderate, and severe groups of periodontitis.

CONCLUSIONS: Our findings indicate that ICAM-1 rs5498 and VCAM-1 rs1041163 polymorphisms contribute to chronic periodontitis, and ICAM-1 rs5498 and VCAM-1 rs1041163 gene polymorphisms might be associated with periodontitis severity in the Heilongjiang Chinese population. Further studies should be conducted to determine whether these polymorphisms could be used as biomarkers of periodontitis.

Keywords: Asian Continental Ancestry Group - genetics, Case-Control Studies, China - epidemiology, Genetic Association Studies, Intercellular Adhesion Molecule-1 - genetics, Periodontal Diseases - genetics, Polymorphism, Single Nucleotide, Risk Factors, Vascular Cell Adhesion Molecule-1 - genetics

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750