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12 October 2016 : Laboratory Research  

MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer

Lingmi HouBC, Maoshan ChenE, Hongwei YangAD, Tianyong XingEF, Jingdong LiC, Guangwu LiBC, Lina ZhangB, Shishan DengCEG, Jiani HuBC, Xiaobo ZhaoG, Jun JiangG

DOI: 10.12659/MSM.897731

Med Sci Monit 2016; 22:3666-3672

Abstract

BACKGROUND: Breast cancer is the main type of cancer in women, and triple-negative breast cancer (TNBC) is a unique subtype of breast cancer. The expression of miR-940 has been shown to play an important role in various cancers; however, the role of miR-940 in TNBC remains unknown.

MATERIAL AND METHODS: The expression of miR-940 in TNBC tissues or cells were tested by qRT-PCR; the expression of miR-940 in cells were overexpressed by miR-940 mimics, and suppressed by anti-miR-940. Bioinformatics algorithms from TargetScanHuman were used to predict the target genes of miR-940. The interaction between miR-940 and ZNF24 was confirmed by dual luciferase assays. The protein level was assayed by Western blot.

RESULTS: TNBC tissues and cells showed lower miR-940 levels.

CONCLUSIONS: MiR-940 inhibited cellular proliferation and migration in TNBC.

Keywords: Cells, Cultured, Kruppel-Like Transcription Factors - metabolism, Prognosis, Triple Negative Breast Neoplasms - pathology

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750