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18 June 2017 : Laboratory Research  

Increased Levels of Pro-Inflammatory and Anti-Inflammatory Cellular Responses in Parkinson’s Disease Patients: Search for a Disease Indicator

Likun Yang1ABCEF, Changfeng Guo2BCE, Jie Zhu1BD, Yi Feng3BD, Weiliang Chen3BE, Zhizhong Feng3BD, Dan Wang3EF, Shibai Sun3DF, Wei Lin3BD, Yuhai Wang1ADFG*

DOI: 10.12659/MSM.904240

Med Sci Monit 2017; 23:2972-2978

Abstract

BACKGROUND: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder and it arises when most of the dopaminergic neurons of substantia nigra region die. Several mechanisms have been postulated as the causative event in PD pathology, and neuroinflammation is most crucial among them.

MATERIAL AND METHODS: We analyzed T-helper 17 (Th17) cells and myeloid-derived suppressor cells (MDSCs) from 80 PD patients to assess inflammatory processes and to find a cost-effective means to evaluate PD prognosis.

RESULTS: We found significantly increased numbers of Th17 cells and MDSCs count in peripheral circulation in PD patients compared with controls (p<0.001). A positive correlation was found between Th17 cells and MDSCs in PD patients (r=0.421, p<0.05).

CONCLUSIONS: Our results show the effector role of Th17 cells and MDSCs in PD pathology and shows their utility as effective biomarkers for PD diagnosis.

Keywords: Biological Markers, Myeloid Cells, neurogenic inflammation, Parkinsonian Disorders, T-Lymphocytes, Helper-Inducer

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750