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25 May 2017 : Clinical Research  

Myocardial Performance Index for Patients with Overt and Subclinical Hypothyroidism

Aziz Karabulut1ABCDEF*, Abdullah Doğan2BCE, Alpaslan Kemal Tuzcu3BCDF

DOI: 10.12659/MSM.905190

Med Sci Monit 2017; 23:2519-2526

Abstract

BACKGROUND: Hypothyroid has several effects on the cardiovascular system. Global myocardial performance index (MPI) is used in assessment of both left ventricular (LV) systolic and diastolic function. We compared MPI in hypothyroidism patients vs. normal control subjects.

MATERIAL AND METHODS: Eighty-two hypothyroid patients were divided into 2 groups: a subclinical hypothyroid (SH) group (n=50), and an overt hypothyroid (OH) group (n=32). The healthy control group (CG) constituted of 37 patients. TSH, FT3, and FT4, anti-TPO, anti-TG, insulin, lipid values, and fasting glucose levels were studied. All patients underwent an echocardiographic examination. Myocardial performance indexes were assessed and standard echocardiographic examinations were investigated.

RESULTS: MPI averages in OH, SH, and control groups were 0.53±0.06, 0.51±0.05, and 0.44±0.75 mm, respectively. MPI was increased in the OH and SH groups in comparison to CG (p<0.001, p<0.001, respectively).

CONCLUSIONS: MPI value was significantly higher in hypothyroid patients in comparison to the control group, showing that regression in global left ventricular functions is an important echocardiographic finding. Future studies are required to determine the effects of this finding on long-term cardiovascular outcomes.

Keywords: Cardiovascular Abnormalities, Echocardiography, Hypothyroidism

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750