30 June 2017 : Laboratory Research
Transcription Factor 21 (TCF21) rs12190287 Polymorphism is Associated with Osteosarcoma Risk and Outcomes in East Chinese Population
Zhenghui Jiang1ABCE*, Weikang Zhang1CD, Zhikang Chen2EF, Jinxiang Shao1BD, Liqiu Chen1CDE, Zhaohui Wang3EGDOI: 10.12659/MSM.905595
Med Sci Monit 2017; 23:3185-3191
Abstract
BACKGROUND: The transcription factor 21 (TCF21) gene is believed to be a tumor suppressor gene. TCF21 gene polymorphisms were found to play a role in the tumorigenesis of some solid malignancies. We raised a hypothesis that genetic polymorphisms of TCF21 were correlated with risk and prognosis of osteosarcoma.
MATERIAL AND METHODS: We recruited 225 young osteosarcoma individuals and 250 cancer-free controls. Five tagging SNPs (TCF21 rs2327429 T>C, rs2327433 A>G, rs2327433 A>G, rs12190287 C>G, and rs4896011 T>A) were genotyped. Preserved DNA samples from blood underwent PCR analysis for genotyping.
RESULTS: rs12190287 C>G is a good predictor of osteosarcoma risk and outcomes. The CG and GG genotypes of rs12190287 predict elevated risk of osteosarcoma. Besides, rs12190287 CG and GG genotypes are associated with Enneking stage and potential in forming metastasis of osteosarcoma.
CONCLUSIONS: Genetic polymorphisms of TCF21 are potentially predictive for osteosarcoma risk and outcomes.
Keywords: Polymorphism, Single Nucleotide, Prognosis
Editorial
01 October 2022 : Editorial
Editorial: Rebound COVID-19 and Cessation of Antiviral Treatment for SARS-CoV-2 with Paxlovid and MolnupiravirDOI: 10.12659/MSM.938532
Med Sci Monit 2022; 28:e938532
SARS-CoV-2/COVID-19
16 September 2022 : Review article
Effects of Physiotherapy on Rehabilitation and Quality of Life in Patients Hospitalized for COVID-19: A Rev...Med Sci Monit In Press; DOI: 10.12659/MSM.938141
12 September 2022 : Clinical Research
Effect of Vitamin D Concentration on Course of COVID-19Med Sci Monit In Press; DOI: 10.12659/MSM.937741
01 October 2022 : Editorial
Editorial: Rebound COVID-19 and Cessation of Antiviral Treatment for SARS-CoV-2 with Paxlovid and MolnupiravirMed Sci Monit 2022; 28:e938532
29 August 2022 : Database Analysis
Transcriptome Analysis of Peripheral Blood Mononuclear Cells Response in Patients with Severe COVID-19 Reve...Med Sci Monit 2022; 28:e937532
In Press
30 Sep 2022 : Clinical Research
Correlation Between Trough Level of Abiraterone and Prostate-Specific Antigen (PSA) Response in Metastatic ...Med Sci Monit In Press; DOI: 10.12659/MSM.938091
30 Sep 2022 : Review article
A Review of the Biological Mechanisms of Dexmedetomidine for Postoperative Neurocognitive DisordersMed Sci Monit In Press; DOI: 10.12659/MSM.937862
29 Sep 2022 : Animal Research
Effect of Antilogous Platelet-Rich Plasma on the Revascularization of Rabbit Prefabricated FlapMed Sci Monit In Press; DOI: 10.12659/MSM.937718
26 Sep 2022 : Clinical Research
Distribution and Determinants of Plasma Homocysteine Levels in a Preconception Population: A Retrospective ...Med Sci Monit In Press; DOI: 10.12659/MSM.937987
Most Viewed Current Articles
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Nov 2020 : Review article
Long-Term Respiratory and Neurological Sequelae of COVID-19DOI :10.12659/MSM.928996
Med Sci Monit 2020; 26:e928996