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07 September 2017 : Clinical Research  

Analysis of Antineutrophil Cytoplasm Antibody from 118 730 Patients in Tertiary Hospitals in Jiangxi Province, China

Liming Tan1ABCDEFG*, Anjun Jiao2ABCDEF, Juanjuan Chen1BCDEF, Xiaojing Feng2BCDE, Liuyue Xu2BCEG, Siqi He2BCDE, Fuyan Tan2BEG, Yongqing Jiang1B, Heng Luo1B, Hua Li1B, Yang Wu1B, Yongjian Tian1B, Tingting Zeng1B, Jianlin Yu1B, Liping Cao1B, Jianfeng Zheng1B, Hui Xu1B, Ming Wei1B, Wen Gan1B, Weihua Peng3B, Yanming Liu4B, Jing Hou5B, Jiangxia Xu6B, LiHua Shuai7B, Wenzhi Huang8B, Junyun Huang8B, Yan Lin9B, Jianrong Liu10B

DOI: 10.12659/MSM.905880

Med Sci Monit 2017; 23:4312-4320

Abstract

BACKGROUND: The discovery of antineutrophil cytoplasm antibody (ANCA) makes the early diagnosis of primary vasculitis possible, and also has important guiding significance for the diagnosis and treatment of secondary vasculitis. This study aimed to investigate the clinical significance of ANCA.

MATERIAL AND METHODS: ANCA was detected by indirect immunofluorescence assay (IIF), and anti-myeloperoxidase (MPO) antibody, and anti-proteinase 3 (PR3) antibody were detected by ELISA. The results were analyzed retrospectively.

RESULTS: Among 118 730 patients, a total of 5853 (4.93%) were positive for ANCA. In the positive cases, 3.98% were male and 6.33% were female, with significant differences (χ²=123.38, P<0.01). For ANCA, the department with the highest positive rate (15.06%) was the Department of Rheumatology, followed by 7.78% in the Department of Dermatology, 6.79% in the Department of Nephrology, and 5.72% in the Department of Traditional Chinese Medicine (TCM). Anti-PR3 and cANCA were highly specific in primary vasculitis (P<0.01). Anti-MPO and pANCA had high specificity for other autoimmune diseases (P<0.01).

CONCLUSIONS: ANCA has important guiding significance for vasculitis-related diseases. Therefore, it is important in the diagnosis and treatment of this disease and has value in clinical practice.

Keywords: Antibodies, Antineutrophil Cytoplasmic, Autoimmune Diseases, Vasculitis

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750