08 August 2017 : Clinical Research
High Prolactin Level as a Predictor of Vasospasm in Aneurysmal Subarachnoidal Hemorrhage
Ilker Çöven1AB, Atilla Kırcelli2DE, Enes Duman3BF, Huseyin Ulas Pınar4BFG, Betul Basaran5BCFDOI: 10.12659/MSM.906010
Med Sci Monit 2017; 23:3831-3836
Abstract
BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) is a destructive syndrome with a mortality rate of 50%. Recent studies have also suggested a high pervasiveness of hypothalamic-pituitary insufficiency in up to 45% of patients after aSAH. Prolactin has been associated with the pathogenesis of hypertensive irregularities that are linked to pregnancy.
MATERIAL AND METHODS: We identified a group of 141 patients with spontaneous SAH due to a ruptured cerebral aneurysm; these patients were operated on at our institution’s Neurosurgery and Interventional Radiology Department between 2011 and June 2015. All of the data were obtained retrospectively from medical records.
RESULTS: The hormonal abnormalities observed in the initial 24 h after ictus in subjects with subarachnoid SAH were caused by stressful stimulation aggravated by intracranial bleeding.
CONCLUSIONS: The elevated prolactin levels that occur in patients with aSAH can be used in conjunction with other auxiliary factors that we believe may be beneficial to vasospasm.
Keywords: prolactin, Subarachnoid Hemorrhage, Vasospasm, Intracranial
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