08 April 2020 : Clinical Research
Long Non-Coding RNA MACC1-AS1 Is Involved in Distant Recurrence of Hepatocellular Carcinoma After Surgical Resection
Yujuan Liu1ACEF, Yuan Zhang2BCD, Tianjin Zhang1ABCEFG*DOI: 10.12659/MSM.921175
Med Sci Monit 2020; 26:e921175
Abstract
BACKGROUND: We explored the role of MACC1-AS1 in hepatocellular carcinoma (HCC).
MATERIAL AND METHODS: Measurement of preoperative plasma levels of MACC1-AS1 was performed by qPCR, and the comparison between the HCC and Control group was performed by unpaired t test. The overexpression of TGF-β1 in SNU-182 and SNU-398 cells was confirmed by qPCR.
RESULTS: MACC1-AS1 was overexpressed in HCC patients. In comparison to pretreatment level, distant recurrence (DR) was accompanied by increased levels of MACC1-AS1 in plasma, but this phenomenon was not observed in cases of local recurrence (LR) or non-recurrence (NR). In HCC cells, MACC1-AS1 positively regulated the expression of TGF-β1. MACC1-AS1 overexpression resulted in increased invasion and migration rates of HCC cells, while siRNA silencing resulted in reduced rates. Moreover, TGF-β1 overexpression reduced the effects of MACC1-AS1 siRNA silencing.
CONCLUSIONS: MACC1-AS1 is involved in the distant recurrence of HCC, and its actions are possibly mediated by TGF-β1.
Keywords: Accommodation, Ocular, Carcinoma, Hepatocellular, Recurrence, Biomarkers, Tumor, Case-Control Studies, Liver Neoplasms, RNA, Antisense, Trans-Activators
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