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Latest Articles

#944243

25 Jul 2024 : Clinical Research  

Olfactory Dysfunction as a Marker for Cognitive Impairment in General Paresis of the Insane: A Clinical Study

Shuang Liang, Ben Chen [...]

DOI: 10.12659/MSM.944243

Med Sci Monit 2024; 30:e944243

#944243

25 Jul 2024 : Clinical Research  

Olfactory Dysfunction as a Marker for Cognitive Impairment in General Paresis of the Insane: A Clinical Study

Shuang Liang, Ben Chen [...]

DOI: 10.12659/MSM.944243

Med Sci Monit 2024; 30:e944243

#943975

24 Jul 2024 : Clinical Research  

Ultrasound-Guided PRP and SVF Therapy Shows Sustained Improvement in Severe Knee Osteoarthritis: A 12-Month Retrospective Study

Savas Comlek ORCID logo, Dilek Baykal ORCID logo [...]

DOI: 10.12659/MSM.943975

Med Sci Monit 2024; 30:e943975

#943975

24 Jul 2024 : Clinical Research  

Ultrasound-Guided PRP and SVF Therapy Shows Sustained Improvement in Severe Knee Osteoarthritis: A 12-Month Retrospective Study

Savas Comlek ORCID logo, Dilek Baykal ORCID logo [...]

DOI: 10.12659/MSM.943975

Med Sci Monit 2024; 30:e943975

#943617

24 Jul 2024 : Review article  

Optimizing Quality of Life in Kidney Transplant Recipients Through Structured Exercise: A Systematic Review and Evidence-Based Guidelines

Wushi Wang,

DOI: 10.12659/MSM.943617

Med Sci Monit 2024; 30:e943617

#943617

24 Jul 2024 : Review article  

Optimizing Quality of Life in Kidney Transplant Recipients Through Structured Exercise: A Systematic Review and Evidence-Based Guidelines

Wushi Wang,

DOI: 10.12659/MSM.943617

Med Sci Monit 2024; 30:e943617

#944727

23 Jul 2024 : Database Analysis  

Trends in HIV/AIDS-Related Mortality and the Impact of Antiretroviral Treatment Strategies in Lu'an City: A Comprehensive Analysis

Rui Shu, Haili Lyu [...]

DOI: 10.12659/MSM.944727

Med Sci Monit 2024; 30:e944727

#944727

23 Jul 2024 : Database Analysis  

Trends in HIV/AIDS-Related Mortality and the Impact of Antiretroviral Treatment Strategies in Lu'an City: A Comprehensive Analysis

Rui Shu, Haili Lyu [...]

DOI: 10.12659/MSM.944727

Med Sci Monit 2024; 30:e944727

#944383

23 Jul 2024 : Database Analysis  

Enhanced Outcomes in Femoral Subtrochanteric Fractures Using Long INTERTAN Nails with Titanium Cable Cerclage: A Retrospective Analysis

Mingjian Bei, Yaping Xiao [...]

DOI: 10.12659/MSM.944383

Med Sci Monit 2024; 30:e944383

#944383

23 Jul 2024 : Database Analysis  

Enhanced Outcomes in Femoral Subtrochanteric Fractures Using Long INTERTAN Nails with Titanium Cable Cerclage: A Retrospective Analysis

Mingjian Bei, Yaping Xiao [...]

DOI: 10.12659/MSM.944383

Med Sci Monit 2024; 30:e944383

0:00
#944297

22 Jul 2024 : Clinical Research  

Reduced Radial Artery Occlusion in Transradial Cerebral Angiography: Key Predictive Factors and Preventive Measures from a Single-Center Study of 543 Patients

Wu Jian, Ranze Cai [...]

DOI: 10.12659/MSM.944297

Med Sci Monit 2024; 30:e944297

#944297

22 Jul 2024 : Clinical Research  

Reduced Radial Artery Occlusion in Transradial Cerebral Angiography: Key Predictive Factors and Preventive Measures from a Single-Center Study of 543 Patients

Wu Jian, Ranze Cai [...]

DOI: 10.12659/MSM.944297

Med Sci Monit 2024; 30:e944297

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#944985

22 Jul 2024 : Clinical Research  

Comparative Analysis of Antihypertensive and Anticonvulsant Regimens in Managing Pre-eclampsia and Eclampsia: Insights from a Sudanese Retrospective Study

Qusay O. Abdalla ORCID logo, Esraa O. Mohammed ORCID logo [...]

DOI: 10.12659/MSM.944985

Med Sci Monit 2024; 30:e944985

#944985

22 Jul 2024 : Clinical Research  

Comparative Analysis of Antihypertensive and Anticonvulsant Regimens in Managing Pre-eclampsia and Eclampsia: Insights from a Sudanese Retrospective Study

Qusay O. Abdalla ORCID logo, Esraa O. Mohammed ORCID logo [...]

DOI: 10.12659/MSM.944985

Med Sci Monit 2024; 30:e944985

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#944526

21 Jul 2024 : Clinical Research  

Cost-Effectiveness Analysis of Hepatic Arterial Chemotherapy for Advanced Hepatocellular Carcinoma in China: A Comparative Analysis of HAIC-FO and Sorafenib

Jie Gao, Shu Liu [...]

DOI: 10.12659/MSM.944526

Med Sci Monit 2024; 30:e944526

#944526

21 Jul 2024 : Clinical Research  

Cost-Effectiveness Analysis of Hepatic Arterial Chemotherapy for Advanced Hepatocellular Carcinoma in China: A Comparative Analysis of HAIC-FO and Sorafenib

Jie Gao, Shu Liu [...]

DOI: 10.12659/MSM.944526

Med Sci Monit 2024; 30:e944526

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#944810

20 Jul 2024 : Clinical Research  

Frontal Plane Body Posture as a Predictor of Musculoskeletal Injuries in Amateur Athletes: A Comprehensive Study of 89 Participants Over 12 Months

Katarzyna Kochan-Jacheć, Dawid Koźlenia ORCID logo [...]

DOI: 10.12659/MSM.944810

Med Sci Monit 2024; 30:e944810

#944810

20 Jul 2024 : Clinical Research  

Frontal Plane Body Posture as a Predictor of Musculoskeletal Injuries in Amateur Athletes: A Comprehensive Study of 89 Participants Over 12 Months

Katarzyna Kochan-Jacheć, Dawid Koźlenia ORCID logo [...]

DOI: 10.12659/MSM.944810

Med Sci Monit 2024; 30:e944810

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#943176

19 Jul 2024 : Clinical Research  

Minimally Invasive versus Traditional Surgery: Efficacy of PELD and PLIF in Treating Pyogenic Spondylodiscitis

Yuan Liu, Tianlong Wu [...]

DOI: 10.12659/MSM.943176

Med Sci Monit 2024; 30:e943176

#943176

19 Jul 2024 : Clinical Research  

Minimally Invasive versus Traditional Surgery: Efficacy of PELD and PLIF in Treating Pyogenic Spondylodiscitis

Yuan Liu, Tianlong Wu [...]

DOI: 10.12659/MSM.943176

Med Sci Monit 2024; 30:e943176

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#944682

18 Jul 2024 : Clinical Research  

Impact of Denture Use on Oral Health-Related Quality of Life in Yemeni Patients: A Cross-Sectional Analysis

Nadhra N. Alalwani ORCID logo, Abbas Mohammed Al-Kebsi [...]

DOI: 10.12659/MSM.944682

Med Sci Monit 2024; 30:e944682

#944682

18 Jul 2024 : Clinical Research  

Impact of Denture Use on Oral Health-Related Quality of Life in Yemeni Patients: A Cross-Sectional Analysis

Nadhra N. Alalwani ORCID logo, Abbas Mohammed Al-Kebsi [...]

DOI: 10.12659/MSM.944682

Med Sci Monit 2024; 30:e944682

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#943170

17 Jul 2024 : Clinical Research  

Prognostic Impact of Tumor-Infiltrating Immune Cells on Efficacy of Neoadjuvant Chemotherapy in Patients with Advanced or Metastatic Ovarian Cancer: A Retrospective Study

Qunxian Rao, Miaoling Huang [...]

DOI: 10.12659/MSM.943170

Med Sci Monit 2024; 30:e943170

#943170

17 Jul 2024 : Clinical Research  

Prognostic Impact of Tumor-Infiltrating Immune Cells on Efficacy of Neoadjuvant Chemotherapy in Patients with Advanced or Metastatic Ovarian Cancer: A Retrospective Study

Qunxian Rao, Miaoling Huang [...]

DOI: 10.12659/MSM.943170

Med Sci Monit 2024; 30:e943170

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#944645

17 Jul 2024 : Clinical Research  

Effects of Ozone Disc Nucleolysis in Management of Herniated Lumbar Intervertebral Disc: A Retrospective Single-Center Study of 149 Patients

Ibrahim Burak Atcı, Okan Turk [...]

DOI: 10.12659/MSM.944645

Med Sci Monit 2024; 30:e944645

#944645

17 Jul 2024 : Clinical Research  

Effects of Ozone Disc Nucleolysis in Management of Herniated Lumbar Intervertebral Disc: A Retrospective Single-Center Study of 149 Patients

Ibrahim Burak Atcı, Okan Turk [...]

DOI: 10.12659/MSM.944645

Med Sci Monit 2024; 30:e944645

0:00

Editorial

01 July 2024 : Editorial  

Editorial: The Global Threats of Increasing Antimicrobial Resistance Require New Approaches to Drug Development, Including Molecular Antimicrobial Adjuvants

Dinah V. Parums

DOI: 10.12659/MSM.945583

Med Sci Monit 2024; 30:e945583

0:00

In Press

Clinical Research  

Endoscopic and Microscopic Tympanoplasty for Adhesive Otitis Media: A Comparative Prospective Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.945152  

Clinical Research  

Status of Professional Identity, Self-Directed Learning Competence, and Self-Efficacy Among Central Sterile...

Med Sci Monit In Press; DOI: 10.12659/MSM.944044  

Clinical Research  

Enhanced Postoperative Pain Management and Mobility Following Arthroscopic Knee Surgery: A Comparative Stud...

Med Sci Monit In Press; DOI: 10.12659/MSM.943735  

Database Analysis  

Impact of Standing and Sitting Postures on Spinal Curvature and Muscle Mechanical Properties in Young Women...

Med Sci Monit In Press; DOI: 10.12659/MSM.944930  

Most Viewed Current Articles

17 Jan 2024 : Review article   4,548,690

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,606,306

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   691,121

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial   50,927

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750
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05 June 2020 : Laboratory Research  

Association of +138I/D and Lys198Asn Polymorphisms in the Endothelin-1 Gene with Early Onset of Coronary Artery Disease among the Chinese Han Population

Guosheng Tu1ADE, Zhengxu Fang1BC, Yu Zhao1BC, Qinghua Wu2AE*

DOI: 10.12659/MSM.921542

Med Sci Monit 2020; 26:e921542

Abstract

BACKGROUND: Human endothelin-1 (ET-1) gene polymorphism is closely associated with coronary artery disease (CAD). This study aimed to investigate the association of 2 single-nucleotide polymorphisms (SNPs), +138 I/D and Lys198Asn) of the ET-1 gene,with early onset of CAD in Han Chinese patients. We investigated the effects of Lys198Asn polymorphism on ET-1 protein expression upon stimulation with pro-inflammatory factors.

MATERIAL AND METHODS: Genotyping of the 2 SNPs +138 I/D and Lys198Asn was performed in 88 early-onset CAD patients (≤55 years for males; ≤60 years for females) and 52 healthy control participants using a polymerase chain reaction direct sequencing method. The association of the 2 SNPs was analyzed with SPSS 17.0 software. Western blotting was performed to assess the effects of ET-1 polymorphisms on ET-1 protein expression upon tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and lipopolysaccharide (LPS) stimulation in HEK-293T cells.

RESULTS: Fisher’s exact test showed that the T allele (odds ratio [OR]=3.38, P=0.02) and GT/TT genotype (OR=3.76, P=0.02) of the ET-1 gene Lys198Asn were associated with increased early-onset CAD risk. Multivariate logistic regression analysis showed smoking was the single independent variable related to early-onset CAD (P<0.05). An increase of ET-1 protein levels in cells transfected with Asn198 plasmid was seen upon TNF-α or IL-6 stimulation.

CONCLUSIONS: T allele frequency in Lys198Asn loci might be associated with the pathogenesis of early-onset CAD. T-variant might contribute to early-onset CAD by upregulating ET-1 expression upon inflammatory cytokines stimulation, and smokers who have the T allele might be vulnerable to CAD in the Chinese population.

Keywords: Coronary Artery Disease, Cytokines, Endothelin-1, Polymorphism, Single Nucleotide, Asians, Case-Control Studies, ethnicity, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Odds Ratio, Risk Factors

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Editorial

01 February 2025 : Editorial  

Editorial: Current Approaches to Screening for Lung Cancer in Smokers and Non-Smokers

Dinah V. Parums

DOI: 10.12659/MSM.948255

Med Sci Monit 2025; 31:e948255

0:00

In Press

Clinical Research  

Correlation Descriptive Study on Nurses' Professional Values and Job Satisfaction and the Ethical Climate o...

Med Sci Monit In Press; DOI: 10.12659/MSM.945639  

Clinical Research  

Pre- and Post-Surgical MRI Analysis of Levator Ani in Pelvic Organ Prolapse Patients: A Single-Center Study

Med Sci Monit In Press; DOI: 10.12659/MSM.945993  

Clinical Research  

Comparative Impact of Kinesio Taping and Post-Isometric Muscle Relaxation on Pain and Myofascial Mechanics ...

Med Sci Monit In Press; DOI: 10.12659/MSM.945376  

Clinical Research  

Surgical Efficacy in Varicocele Ligation with Ephedrine-Assisted Blood Pressure Control

Med Sci Monit In Press; DOI: 10.12659/MSM.946234  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,968,210

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   701,772

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Mar 2024 : Editorial   25,357

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...

DOI :10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

28 Jan 2024 : Review article   19,972

A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future

DOI :10.12659/MSM.943912

Med Sci Monit 2024; 30:e943912

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750