06 June 2020 : Laboratory Research
Antimicrobial Activity of Nano-Magnesium Hydroxide Against Oral Bacteria and Application in Root Canal Sealer
Yingying Meng12ABCDEF, Dan Zhang12ADF, Xingya Jia12AEF, Keshen Xiao3AC, Xiao Lin4DE, Yi Yang5AF, Dake Xu5DE, Qiang Wang12G*DOI: 10.12659/MSM.922920
Med Sci Monit 2020; 26:e922920
Abstract
BACKGROUND: The goal of the present work was to assess the antibacterial activity of nano-magnesium hydroxide (NMH) against Streptococcus mutans (S. mutans) and to explore the antimicrobial function of AH Plus™ sealer incorporating NMH.
MATERIAL AND METHODS: The antimicrobial behavior of NMH against S. mutans was evaluated with bactericidal tests. A modified direct contact test was used to assess the antimicrobial activity of unset AH Plus containing NMH after 5 minutes, 20 minutes, and 60 minutes of contact with bacteria. The antimicrobial effects and the amount of surface-adhering bacteria of the solidified materials were explored by SEM and confocal laser scanning microscopy, respectively.
RESULTS: NMH powder presented excellent antimicrobial activity against S. mutans. Mg²⁺ and OH⁻ were not the main factors resulting in bacterial death. Approximately 93.1% and 98% of the S. mutans were killed in the AH Plus+7% NMH group after incubation for 5 minutes and 20 minutes, respectively. AH Plus with 5% or 7% NMH were more potent against S. mutans compared with AH Plus alone (P<0.05). Moreover, the antibacterial function of AH Plus was lost after setting. NMH enabled the solidified AH Plus to still have antibacterial properties on the seventh day.
CONCLUSIONS: NMH can be used to modify AH Plus sealer to eradicate residual bacteria and prevent reinfection.
Keywords: Magnesium Hydroxide, Root Canal Therapy, Streptococcus mutans, Anti-Bacterial Agents, Anti-Infective Agents, Biofilms, China, Materials Testing, Root Canal Filling Materials, Zinc Oxide-Eugenol Cement
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