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23 April 2020 : Animal Research  

Effect of Sleeve Gastrectomy on Bone Metabolism and Serum 5-Hydroxytryptamine in Obese Rats

Kai Xu12ACDEF, Junxing Ma3BCD, Zhi Liu1ABC, Xiaoyang Wang1BCF, Shaohua Yan12BC, Zitian Liu12EF, Fuyun Sun12BCE, Kexin Wang1AG*

DOI: 10.12659/MSM.924097

Med Sci Monit 2020; 26:e924097

Abstract

BACKGROUND: Studies have shown that bariatric surgery, such as sleeve gastrectomy (SG), has an adverse effect on bone, including decreased bone mineral density (BMD) and bone metabolism. Peripheral 5-hydroxytryptamine (5-HT) has an adverse regulatory effect on bone formation. Here, we assessed changes in bone metabolism and whether 5-HT is involved in the effect of SG on bone metabolism.

MATERIAL AND METHODS: A rat model of obesity was established using Wistar rats. After successful modeling, rats were randomly assigned to 2 groups – the SG group and the Sham group – with 10 rats in each group. We then performed sleeve gastrectomy or sham operation. Bone metabolic markers and BMD of rats were measured at 2 and 16 weeks after the operation and the level of 5-HT in serum was determined. Rats were killed at 16 weeks after the operation, and bones of the hind limbs were harvested to measure 5-HT by immunofluorescence.

RESULTS: BMD was decreased and bone metabolism demonstrated a trend of bone destruction in the rats after SG. A significantly increasing trend in the level of serum 5-HT was found, and bone immunofluorescence showed increased expression of 5-HT.

CONCLUSIONS: BMD was decrease and bone metabolism demonstrated a trend of bone destruction after SG. SG can affect the level of 5-HT in serum or bone tissue and the 5-HT may be involved in the process through which SG affects bone metabolism.

Keywords: Bone Density, Gastrectomy, Metabolism, Receptor, Serotonin, 5-HT1A, Bariatric Surgery, Bone and Bones, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Obesity, Obesity, Morbid, Rats, Wistar, Serotonin, Weight Loss

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750