22 May 2026 : Clinical Research
[In Press] Association Between Radiographic Knee Osteoarthritis, Pre-Fracture Mobility, and Hip Fracture Patterns in Older Adult Patients: A Retrospective Cohort Study
Süleyman Kaan ÖnerDOI: 10.12659/MSM.952678
Med Sci Monit In Press; DOI: 10.12659/MSM.952678
Available online: 2026-05-22, In Press, Corrected Proof
Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule
Abstract
BACKGROUND
Hip fracture morphology in older adults is influenced not only by bone mineral density but also by biomechanical and functional factors. Knee osteoarthritis (KOA) can alter lower-limb alignment, load distribution, and gait patterns, potentially affecting the type of hip fracture sustained. This study aimed to evaluate the association between radiographic KOA and hip fracture type while accounting for osteoporosis and pre-fracture mobility.
MATERIAL AND METHODS
This single-center retrospective cohort study included patients aged ≥65 years admitted with low-energy hip fractures between January 2018 and December 2023. Radiographic KOA was assessed using Kellgren-Lawrence classification, defined as grade ≥2. Osteoporosis was evaluated using dual-energy X-ray absorptiometry within 1 year before fracture. Pre-fracture mobility was assessed using the Parker Mobility Score, categorized as high (7-9), moderate (4-6), or low (0-3). Hip fractures were classified as femoral neck or intertrochanteric. Multivariable logistic regression identified predictors of intertrochanteric fracture.
RESULTS
Ninety-two patients (mean age 79.1±7.8 years; 67.4% female) were included. Intertrochanteric fractures occurred in 55 patients (59.8%). KOA was present in 56 patients (60.9%), and osteoporosis in 64 (69.6%). Intertrochanteric fractures were more common in patients with KOA (71.4% vs 41.7%, P=0.006). Low mobility was also associated with higher rates (79.4% vs 54.8% vs 40.7%, P=0.007). KOA (OR 2.87; 95% CI, 1.18-6.99; P=0.020) and low mobility (OR 3.41; 95% CI, 1.42-8.19; P=0.006) were independent predictors, whereas osteoporosis was not.
CONCLUSIONS
KOA and reduced mobility were found to be independently associated with intertrochanteric fracture patterns, underscoring the role of biomechanical and functional factors beyond bone density.
Keywords: Hip Fractures; Mobility Limitation; Orthopedics; Osteoporosis; Retrospective Studies
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