07 July 2026 : Clinical Research
[In Press] Retrospective Cohort Study Comparing Digitally Customized 3D-Printed Partial Talus Replacement and Ankle Arthrodesis for Extensive Talus Necrosis: Early Clinical Outcomes
Heda Liu12AEG, Pengwei Li1BF, Fei Huang1BC, Lin Liu1C, Sheng Liu1C, Ming Li2ADOI: 10.12659/MSM.953450
Med Sci Monit In Press; DOI: 10.12659/MSM.953450
Available online: 2026-07-07, In Press, Corrected Proof
Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule
Abstract
BACKGROUND
This retrospective study from a single center included 105 patients with avascular necrosis of the talus in our hospital from January 2021 to January 2024 and aimed to compare outcomes from management with customized 3-dimensional (3D) printed partial talus replacement with ankle arthrodesis.
MATERIAL AND METHODS
The replacement group (n=49) received digital customized 3D-printed partial talus replacement surgery, and the arthrodesis group (n=53) underwent ankle arthrodesis. Efficacy of the 2 surgical methods was evaluated by comparing the American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, pain visual analog scale (VAS), ankle range of motion (ROM), SF-36 quality of life scale, and complication rate before surgery and at last follow-up.
RESULTS
At final follow-up, the observation group showed significantly better outcomes than the conventional group in AOFAS score (85.88±3.56 vs 78.51±4.12, P<0.001), ankle ROM (48.31°±4.95° vs 0.91°±1.13°, P<0.001), and the SF-36 Physical Component Summary (74.12±4.10 vs 55.83±4.96, P<0.001) and Mental Component Summary (81.26±5.12 vs 68.15±5.93, P<0.001). VAS scores were also significantly lower in the observation group (1.71±0.71 vs 2.57±0.87, P<0.001). Overall complication rates were similar (8.1% vs 11.3%, P=0.592); however, the reoperation rate was lower in the observation group (0% vs 3.7%).
CONCLUSIONS
In early follow-up, 3D-printed partial talus replacement for extensive talus necrosis demonstrates superior joint function, ROM, and quality of life compared with ankle arthrodesis, without increasing complications, suggesting it is a safe and effective joint-preserving alternative.
Keywords: Arthrodesis; Printing, Three-Dimensional; Talus
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