23 January 2019 : Clinical Research
Neuron-Specific Enolase Is an Independent Prognostic Factor in Resected Lung Adenocarcinoma Patients with Anaplastic Lymphoma Kinase Gene Rearrangements
Shouying Li123E, Lianjing Cao123D, Xinyue Wang123C, Fan Wang123B, Liuchun Wang123F, Richeng Jiang123A*DOI: 10.12659/MSM.913054
Med Sci Monit 2019; 25:675-690
Abstract
BACKGROUND: An extensive body of research reveals the clinical value of serum tumor markers in lung cancer patients, including carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCCA), cytokeratin-19 fragments (Cyfra21-1), and neuron-specific enolase (NSE), but little is known about the clinical properties of these serum tumor markers in anaplastic lymphoma kinase (ALK)-positive lung cancer patients.
MATERIAL AND METHODS: We retrospectively analyzed 54 patients harboring ALK rearrangements and 520 patients without ALK rearrangements, and all these patients were treated exclusively by surgery between 2011 and 2016.
RESULTS: NSE level (P=0.007 for OS) was identified as an independent prognostic factor among patients with resected ALK-positive adenocarcinoma of the lung.
CONCLUSIONS: A high level of NSE is associated with worse outcome among resected lung adenocarcinoma patients harboring ALK rearrangements.
Keywords: Carcinoembryonic Antigen, Phosphopyruvate Hydratase, Adenocarcinoma of Lung, Aged, 80 and over, Anaplastic Lymphoma Kinase, Biomarkers, Tumor, Carcinoma, Squamous Cell, Keratin-19
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