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22 May 2003

Insulin resistance in the first-degree relatives of persons with type 2 diabetes

Marek Strączkowski, Irina Kowalska, Agnieszka Stępień, Stella Dzienis-Strączkowska, Małgorzata Szelachowska, Ida Kinalska, Agnieszka Krukowska, Marta Konicka

Med Sci Monit 2003; 9(5): CR186-190 :: ID: 11076

Abstract

Background: Type 2 diabetes is characterized by impaired insulin secretion and insulin resistance. Both genetic and environmental factors are thought to play a role in the pathogenesis of this disease.
Obesity is associated with increased risk of type 2 diabetes, but some metabolic abnormalities may also be present in lean, predisposed subjects. The aim of the present study was to assess insulin sensitivity in lean normoglycemic offspring of parents with type 2 diabetes.
Material/Methods: We examined 17 lean offspring (BMI

Keywords: Insulin Resistance - physiology

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750