06 January 2004
Relationship of intercellular adhesion molecule-3 and hepatocyte growth factor with amyloidosis A in chronic renal-failure patientsBanu Bilezikci, Asuman Nihan Haberal, Beyhan Demirhan
Med Sci Monit 2004; 10(1): CR25-28 :: ID: 11552
Background:Patients with chronic renal failure have elevated serum levels of intercellular adhesion molecules and hepatocyte growth factor. The aim of this study was to investigate immunohistochemically whether these substances are associated with amyloidosis A in this patient group.Material/Methods: Liver needle-biopsy specimens from 40 chronic renal-failure patients, 20 with amyloidosis A (Group I) and 20 without this disease (Group II), were investigated. Twenty control liver biopsies were obtained from healthy individuals (Group III). All specimens were immunohistochemically stained to determine the presence and density of hepatocyte growth factor and intercellular adhesion molecule-3.Results: The levels of positivity for hepatocyte growth factor and intercellular adhesion molecule-3 in Groups I and II were significantly higher than the levels in the control group. Also, the Group I sections had significantly more cells that were positive for intercellular adhesion molecule-3 than the Group II sections (p<0.016). There was no significant difference between Groups I and II regarding the level of positivity for hepatocyte growth factor.
Conclusions: The fact that there was a higher density of intercellular adhesion molecule-3-positive cells in the patients with amyloidosis A indicates that this substance may be a microenvironmental factor in this disease. If this is true, regulating the serum level of this molecule may prevent amyloid A in chronic renal-failure patients.
Keywords: Amyloidosis - complications, Amyloidosis - metabolism, Amyloidosis - prevention & control, Case-Control Studies, Cell Adhesion Molecules - blood, Cell Adhesion Molecules - metabolism, Hepatocyte Growth Factor - metabolism, Kidney Failure, Chronic - complications, Kidney Failure, Chronic - metabolism, Liver - metabolism, Serum Amyloid A Protein - metabolism, Amyloidosis - prevention & control, Case-Control Studies, Cell Adhesion Molecules - metabolism, Hepatocyte Growth Factor - metabolism, Kidney Failure, Chronic - metabolism, Liver - metabolism, Serum Amyloid A Protein - metabolism
01 June 2023 : EditorialEditorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness
Med Sci Monit 2023; 29:e941209
01 Jun 2023 : Clinical ResearchRoot Canal Numbers and Configurations in 1080 Permanent Canine Teeth in 270 Saudi Subjects Using Cone-Beam ...
Med Sci Monit In Press; DOI: 10.12659/MSM.940472
01 Jun 2023 : Clinical ResearchInternal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s Disease
Med Sci Monit In Press; DOI: 10.12659/MSM.940873
01 Jun 2023 : Clinical ResearchEffectiveness of Needle Aspiration versus Surgical Excision for Symptomatic Synovial Cysts of the Hip: A Si...
Med Sci Monit In Press; DOI: 10.12659/MSM.940187
01 Jun 2023 : Clinical ResearchInfluence of Insulin Resistance on Diabetes Nephropathy
Med Sci Monit In Press; DOI: 10.12659/MSM.939482
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952