Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

06 January 2004

Expression of TGFß1 genes and their receptor types I, II, and III in low- and high-grade malignancy non-Hodgkin’s lymphomas

Dariusz Woszczyk, Joanna Gola, Magdalena Jurzak, Urszula Mazurek, Joanna Mykała-Cieśla, Tadeusz Wilczok

Med Sci Monit 2004; 10(1): CR33-37 :: ID: 11569

Abstract

Background:Transforming growth factor beta (TGFß) is involved in a variety of important cellular functions. The lack of TGFß-dependent cell-growth control might be related to oncogenesis, as it has been shown in lung, breast, and colon carcinomas. Current observations have revealed that TGFß is rather an inhibiting, not a stimulating, factor as far as malignant tumor development is concerned. Recently, however, there has been a growing number of reports on increased expression of TGFß genes in certain tumors. In patients with a diagnosis of non-small-cell lung carcinoma, the tumors expressing high levels of TGFß were the ones that had a higher proliferation and metastasis capability, whereas more promising were the cases with lower levels of TGFß expression.Material/Methods: A pilot study of 14 patients was conducted comprising 8 patients with a low-grade lymphoma and 6 patients with a high-grade lymphoma. The QRT-PCR method was employed to assess the activity of TGFß1 and of its receptor types I, II, and III.Results: The expression values for TGFß1 and its receptors I, II, and III were twice as high in the group of patients with a diagnosis of high-grade lymphomas as in the group of patients diagnosed with low-grade lymphomas.Conclusions: Results showed a clear difference in TGFß1 expression in patients with NHL depending on the subtype of the lymphoma, suggesting its significant role in the pathomechanism of this group of malignant diseases as well as its potential value as a prognostic factor.

Keywords: Activin Receptors, Type I - genetics, Base Sequence, DNA Primers - genetics, Lymphoma, High-Grade - genetics, Lymphoma, High-Grade - immunology, Lymphoma, Low-Grade - genetics, Lymphoma, Low-Grade - immunology, Pilot Projects, Proteoglycans - genetics, RNA, Messenger - genetics, RNA, Messenger - metabolism, Receptors, Transforming Growth Factor beta - genetics, Reverse Transcriptase Polymerase Chain Reaction, Transforming Growth Factor beta - genetics, Transforming Growth Factor beta1, Activin Receptors, Type I - genetics, Base Sequence, DNA Primers - genetics, Lymphoma, Non-Hodgkin - immunology, Pilot Projects, Protein-Serine-Threonine Kinases, Proteoglycans - genetics, RNA, Messenger - metabolism, Receptors, Transforming Growth Factor beta - genetics, Reverse Transcriptase Polymerase Chain Reaction, Transforming Growth Factor beta - genetics, Transforming Growth Factor beta1

Add Comment 0 Comments

Editorial

01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

Clinical Research  

Comparative Efficacy of Micro-Needle-Knife Therapy and Acupuncture in Acute Ankle Sprains: A Randomized Con...

Med Sci Monit In Press; DOI: 10.12659/MSM.944157  

0:00

Clinical Research  

The Influence of Gestational Diabetes Mellitus on Maternal and Neonatal Outcomes: A Retrospective Study in ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943644  

0:00

Clinical Research  

Exploring the Educational Social and Physical Activities Among Health Care Undergraduates – a Cross-Section...

Med Sci Monit In Press; DOI: 10.12659/MSM.943399  

Clinical Research  

Percutaneous Coronary Intervention as a Non-Surgical Treatment for Ischemic Mitral Regurgitation in Patient...

Med Sci Monit In Press; DOI: 10.12659/MSM.943122  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750