Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 March 2004

Gabexate mesilate and heparin responsiveness in coronary patients

Marco Ranucci

Med Sci Monit 2004; 10(3): PI40-43 :: ID: 11610

Abstract

Background: Heparin responsiveness in patients undergoing coronary operations changes depending on many individual factors. Reduced sensitivity to heparin is a common feature and may determine a difficult intraoperative anticoagulation. The aim of this study was to determine the effectiveness of a novel serine proteases inhibitor (gabexate mesilate) in increasing heparin responsiveness.
Material/Methods: 20 patients undergoing coronary operations with cardiopulmonary bypass were studied with respect to their heparin responsiveness. This was measured using individual dose/response tests with a heparin monitoring system before and after a 10-minute intravenous infusion of 2 mg·kg–1·h–1 of gabexate mesilate, a direct inhibitor of factor Xa, thrombin, kallikrein, and other serine proteases. The complete test was performed before initiating the surgical maneuvers.
Results: At each heparin concentration, gabexate mesilate produced a significant prolongation of the kaolin-activated clotting time. The heparin responsiveness (seconds·IU–1·ml–1) in terms of activated clotting time significantly (p=0.007) increased from the baseline of 68.1±13.8 to 74.7±16.1 during infusion, and the heparin loading dose (IU/kg) required to reach the target activated clotting time of 480 seconds significantly (p=0.009) decreased from the baseline of 290±82.3 to 260±77.6 during gabexate mesilate infusion.
Conclusions: Gabexate mesilate significantly increases individual heparin responsiveness in coronary patients. Its use in the treatment of patients with a reduced sensitivity to heparin may support or replace the conventional therapeutic approach based on fresh frozen plasma or purified antithrombin.

Keywords: Antithrombins - metabolism, Bleeding Time, Blood Coagulation, Coronary Disease - drug therapy, Factor Xa - antagonists & inhibitors, Gabexate - pharmacology, Heparin - metabolism, Heparin - pharmacology, Kallikreins - antagonists & inhibitors, Serine Proteinase Inhibitors - pharmacology, Thrombin - antagonists & inhibitors, Time Factors, Antithrombins - metabolism, Bleeding Time, Blood Coagulation, Coronary Disease - drug therapy, Factor Xa - antagonists & inhibitors, Gabexate - pharmacology, Heparin - pharmacology, Kallikreins - antagonists & inhibitors, Serine Proteinase Inhibitors - pharmacology, Thrombin - antagonists & inhibitors, Time Factors

Add Comment 0 Comments

Editorial

01 October 2024 : Editorial  

Editorial: Potentials and Pitfalls in Targeting Glucagon-Like Peptide-1 (GLP-1) in the Management of Increasing Levels of Obesity

Dinah V. Parums

DOI: 10.12659/MSM.946675

Med Sci Monit 2024; 30:e946675

0:00

In Press

Clinical Research  

Predicting Neonatal Hypoglycemia Using AI Neural Networks in Infants from Mothers with Gestational Diabetes...

Med Sci Monit In Press; DOI: 10.12659/MSM.944513  

Clinical Research  

Minimally Invasive Combined Medial and Lateral Approach for Treating Displaced Scapular Body and Neck Fract...

Med Sci Monit In Press; DOI: 10.12659/MSM.945535  

Clinical Research  

Evaluation of Neuromuscular Blockade: A Comparative Study of TOF-Cuff® on the Lower Leg and TOF-Scan® on th...

Med Sci Monit In Press; DOI: 10.12659/MSM.945227  

Clinical Research  

Acupuncture Enhances Quality of Life and Disease Control in Chronic Spontaneous Urticaria Patients on Omali...

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,057,160

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,850,676

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   693,861

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

07 Jan 2022 : Meta-Analysis   258,144

Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...

DOI :10.12659/MSM.935074

Med Sci Monit 2022; 28:e935074

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750