01 April 2004
Proinflammatory cytokines increase iron uptake into human monocytes and synovial fibroblasts from patients with rheumatoid arthritisJoan F. Telfer, Jeremy H. Brock
Med Sci Monit 2004; 10(4): BR91-95 :: ID: 11624
Background:It has been hypothesized that iron is stored in the synovium of patients with rheumatoid arthritis which perpetuates inflammation by aiding the production of oxygen free radicals. Proinflammatory cytokines are produced by macrophages and lymphocytes present within synovium and by mononuclear cells of in synovial fluid from patients with rheumatoid arthritis. There are two known systems for iron uptake. The first involves binding of iron to transferrin and uptake via transferrin receptors. The second involves uptake by low molecular weight organic anions such as ascorbate and citrate (non-transferrin bound uptake).
Material/Methods: Proinflammatory cytokines (IL-1, Il-6, TNF? and interferon ?) were added to fibroblasts isolated from patients with rheumatoid arthritis and human monocytes in culture and their effect on [sup]59[/sup]Fe-transferrin and citrate uptake was determined.
Results: Proinflammatory cytokines increase transferrin and non-transferrin bound iron uptake into human monocytes and increase transferrin-bound iron uptake by synovial fibroblasts, but have no effect on non-transferrin bound uptake into fibroblasts.
Conclusions: Proinflammatory cytokines produced in human rheumatoid arthritis synovium and synovial fluid may contribute to the accumulation of iron that occurs in rheumatoid arthritis synovium which may lead to damage to synovial fibroblasts, macrophages and lymphocytes.
Keywords: Arthritis, Rheumatoid - metabolism, Cells, Cultured, Citrates - metabolism, Cytokines - pharmacology, Fibroblasts - drug effects, Fibroblasts - metabolism, Iron - metabolism, Monocytes - drug effects, Monocytes - metabolism, Synovial Membrane - drug effects, Synovial Membrane - metabolism, Transferrin - metabolism, Arthritis, Rheumatoid - metabolism, Cells, Cultured, Citrates - metabolism, Cytokines - pharmacology, Fibroblasts - metabolism, Iron - metabolism, Monocytes - metabolism, Synovial Membrane - metabolism, Transferrin - metabolism
04 June 2022 : EditorialEditorial: Acute Hepatitis of Unknown Origin in Children. Is Autoimmunity at Play?
Med Sci Monit 2022; 28:e937371
23 Jun 2022 : Clinical ResearchA Real-World Study to Compare the Safety and Efficacy of Paritaprevir/Ombitasvir/Ritonavir and Dasabuvir, w...
Med Sci Monit In Press; DOI: 10.12659/MSM.936706
22 Jun 2022 : Clinical ResearchA Single-Center Study Comparing the Effects of Thoracic Spine Manipulation vs Mobility Exercises in 26 Offi...
Med Sci Monit In Press; DOI: 10.12659/MSM.937316
21 Jun 2022 : Clinical ResearchOptimal Timing and Outcomes of Minimally Invasive Approach in Acute Biliary Pancreatitis
Med Sci Monit In Press; DOI: 10.12659/MSM.937016
Most Viewed Current Articles
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Nov 2020 : Review articleLong-Term Respiratory and Neurological Sequelae of COVID-19
Med Sci Monit 2020; 26:e928996