In this paper we highlight the role and contributions of Latin American researchers in the study of systemic lupus erythematosus (SLE). The first case of SLE in the world was probably from a mummy from the Huary culture in Peru from about 890 AD, which was extensively studied by macroscopic examination and with light and electronic microscopy, as well as conventional radiography. From the end of the 19[sup]th[/sup] century to the present date there have been many contributions of Latin Americans to the knowledge base of SLE. In this article, we discuss the initial observations of SLE in Latin America and then more specifically review the most important contributions to knowledge about SLE made by physicians in individual Latin American countries, as well as the Gladel group (Latin American group for the study of SLE). The investigation of lupus continues to be pursued by a very dedicated group of Latin American researchers, who continue to enhance our understanding of the pathogenesis and treatment of this condition.

Keywords: Clinical Trials, History, 19th Century, History, 20th Century, History, 21st Century, Latin America, Lupus Erythematosus, Systemic - ethnology, Lupus Erythematosus, Systemic - history, Lupus Erythematosus, Systemic - pathology, Lupus Erythematosus, Systemic - therapy, Clinical Trials as Topic, History, 19th Century, History, 20th Century, History, 21st Century, Latin America, Lupus Erythematosus, Systemic - therapy