Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

02 July 2004

Systematic review of the accuracy of the ParaSight™-F test in the diagnosis of Plasmodium falciparum malaria

Mario Cruciani, Stefano Nardi, Marina Malena, Oliviero Bosco, Giovanni Serpelloni, Carlo Mengoli

Med Sci Monit 2004; 10(7): MT81-88 :: ID: 11715

Abstract

Background:The Parasight™-F test is a device for the rapid diagnosis of Plasmodium falciparum malaria. In a number of field studies rather wide disparities in the performance of the test have been reported. To provide an evaluation of the quality of available reports and an overall summary of diagnostic accuracy of the Parasight™-F test, we have performed a systematic review.
Material/Methods:Systematic review and meta-analysis of controlled studies evaluating the diagnostic accuracy of Parasight™-F test in comparison with light microscopy. Data sources: 15,359 subjects (4,119 with falciparum malaria) studied with the Parasight™-F test as reported in 32 studies from 29 publications. Main outcome measures: Summary receiving operator characteristic (SROC) curve as well as odds ratio calculated by the fixed effect model and the random effect model. Based on pooled data, the predictive values were calculated for a range of P. falciparum prevalence through a Bayesian approach.
Results:Overall, the Parasight™-F test demonstrated 0.90 (95%, confidence intervals 0.88–0.93) sensitivity and 0.94 (0.92–0.96) specificity. Both sensitivity and specificity were significantly higher in the non-resident than in the resident population. The post-test probability indicates that in settings of low malaria prevalence, a negative test almost absolutely excludes infection, while in settings of high prevalence, the same result still gives a substantial chance of infection being present.
Conclusions:The Parasight™-F test is a simple and accurate test for the diagnosis of P. falciparum infection. The test could be of particular value in the diagnosis of malaria in travelers returning from endemic areas.

Keywords: Antigens, Protozoan - immunology, Confidence Intervals, Malaria, Falciparum - diagnosis, Malaria, Falciparum - parasitology, Microscopy, Odds Ratio, Plasmodium falciparum - immunology, Predictive Value of Tests, Prevalence, Reagent Kits, Diagnostic - standards, Reagent Kits, Diagnostic - statistics & numerical data, Sensitivity and Specificity, Antigens, Protozoan - immunology, Confidence Intervals, Malaria, Falciparum - parasitology, Microscopy, Odds Ratio, Plasmodium falciparum - immunology, Predictive Value of Tests, Prevalence, Reagent Kits, Diagnostic - statistics & numerical data, Sensitivity and Specificity

Add Comment 0 Comments

Editorial

01 July 2024 : Editorial  

Editorial: The Global Threats of Increasing Antimicrobial Resistance Require New Approaches to Drug Development, Including Molecular Antimicrobial Adjuvants

Dinah V. Parums

DOI: 10.12659/MSM.945583

Med Sci Monit 2024; 30:e945583

0:00

In Press

Clinical Research  

Gender-Based Variation in Alveolar Bone Thickness of Maxillary Incisor Teeth: A CBCT Retrospective Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944588  

0:00

Clinical Research  

Comparison of Adaptations in the Gastrocnemius Muscle from an Exercise Program with and without Low-Intensi...

Med Sci Monit In Press; DOI: 10.12659/MSM.944627  

Clinical Research  

Assessment of Digital Dentistry Knowledge and Practices Among Dental Students at King Faisal University, Sa...

Med Sci Monit In Press; DOI: 10.12659/MSM.944692  

Database Analysis  

Local Government Initiatives: A Comprehensive Analysis of Infertility Diagnostic and Treatment Programs in ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943976  

Most Viewed Current Articles

17 Jan 2024 : Review article   3,561,143

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,585,085

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   690,853

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial   50,667

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750